Abstract
Purpose: To describe the presence of congenital scoliosis in a genetically identical population as it relates to the possible genetic vs. environmental etiologic factors. Methods: The authors describe three cases of congenital scoliosis in monozygotic twins. The first pair includes two 4-year-old girls presenting with mirror curves, one of whom had an associated stage I Chiari malformation. The second pair is a 4-year-old girl who presented with thoracic scoliosis, a T10–11 hemivertebra, and multilevel failure of segmentation in the lumbar spine whose identical sibling is unaffected. The third pair includes a 4-month-old boy with T9 and L4 hemivertebra whose brother is also unaffected. Results: All three cases were managed conservatively with observation and remained asymptomatic throughout the duration of follow-up. There were no associations with extraspinal deformities, although one patient presented with concomitant type I Chiari malformation. Conclusion: The variable presentation of congenital scoliosis in a genetically unique population serves as testament to the complexity associated with its development, likely involving both environmental factors and a genetic predisposition.
Original language | English (US) |
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Pages (from-to) | 533-537 |
Number of pages | 5 |
Journal | European Spine Journal |
Volume | 27 |
DOIs | |
State | Published - Jul 1 2018 |
Keywords
- Chiari malformation
- Congenital scoliosis
- Hemivertebra
- Monozygotic twins
ASJC Scopus subject areas
- Surgery
- Orthopedics and Sports Medicine