The Essence of Aging

Jan Vijg; Brian K. Kennedy

doi:10.1159/000439348

The Essence of Aging

Jan Vijg, Brian K. Kennedy

Genetics

Research output: Contribution to journal › Review article › peer-review

24 Scopus citations

Abstract

The idea that aging is a purposeful, programmed series of events is intuitively appealing based on its many conserved aspects and the demonstrated feasibility of modifying life span by manipulating single genes or pathways. Yet, the case for a nonadaptive basis of aging is strong and now all but generally accepted in the field. Here, we briefly review why the case for programmed aging is weak, with a focus on the lack of possible evolutionary beneficial effects.

Original language	English (US)
Pages (from-to)	381-385
Number of pages	5
Journal	Gerontology
Volume	62
Issue number	4
DOIs	https://doi.org/10.1159/000439348
State	Published - Jun 15 2016

Keywords

Adaptive theories
Antagonistic pleiotropy
Dietary restriction
Programmed aging

ASJC Scopus subject areas

Aging
Geriatrics and Gerontology

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10.1159/000439348

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The Essence of Aging

Abstract

Keywords

ASJC Scopus subject areas

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