The epidemiology of cervical cancer

Eduardo L. Franco, Nicolas F. Schlecht, Debbie Saslow

Research output: Contribution to journalArticle

170 Citations (Scopus)

Abstract

Cervical cancer is one of the most common neoplastic diseases affecting women, with a combined worldwide incidence of almost half a million new cases annually, second only to breast cancer. Basic and epidemiologic research conducted during the past 15-20 years have provided overwhelming evidence for an etiologic role for infection with certain types of sexually-transmitted human papillomavirus (HPV) as the primary cause of cervical cancer. The relative risks of cervical cancer following HPV infection as ascertained in case-control and cohort studies are among the highest in cancer epidemiology. The available evidence indicates that the HPV-cervical cancer association satisfies all relevant causal criteria for public health action. Other cervical cancer risk factors, such as smoking, parity, use of oral contraceptives, diet, other infections, and host susceptibility traits must be understood in the context of mediation of acquisition of HPV infection or in influencing events of the natural history of cervical neoplasia that occur following the establishment of a persistent HPV infection. Virtually all cervical carcinoma specimens contain HPV DNA, which suggests that HPV infection is a necessary cause of cervical neoplasia. This is the first instance in which a necessary cause has been demonstrated in cancer epidemiology-a realization that has obvious implications for primary and secondary prevention of this neoplastic disease.

Original languageEnglish (US)
Pages (from-to)348-359
Number of pages12
JournalCancer Journal
Volume9
Issue number5
DOIs
StatePublished - Sep 2003
Externally publishedYes

Fingerprint

Uterine Cervical Neoplasms
Epidemiology
Papillomavirus Infections
Neoplasms
Primary Prevention
Oral Contraceptives
Secondary Prevention
Infection
Parity
Case-Control Studies
Cohort Studies
Public Health
Smoking
Breast Neoplasms
Diet
Carcinoma
DNA
Incidence
Research

Keywords

  • Cervical neoplasms
  • CIN
  • Epidemiology
  • Human papillomavirus
  • Pap test
  • Prevention
  • Screening

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Franco, E. L., Schlecht, N. F., & Saslow, D. (2003). The epidemiology of cervical cancer. Cancer Journal, 9(5), 348-359. https://doi.org/10.1097/00130404-200309000-00004

The epidemiology of cervical cancer. / Franco, Eduardo L.; Schlecht, Nicolas F.; Saslow, Debbie.

In: Cancer Journal, Vol. 9, No. 5, 09.2003, p. 348-359.

Research output: Contribution to journalArticle

Franco, EL, Schlecht, NF & Saslow, D 2003, 'The epidemiology of cervical cancer', Cancer Journal, vol. 9, no. 5, pp. 348-359. https://doi.org/10.1097/00130404-200309000-00004
Franco, Eduardo L. ; Schlecht, Nicolas F. ; Saslow, Debbie. / The epidemiology of cervical cancer. In: Cancer Journal. 2003 ; Vol. 9, No. 5. pp. 348-359.
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