The enigmatic role of growth hormone in age-related diseases, cognition, and longevity

Gabriela Colon, Tatiana Saccon, Augusto Schneider, Marcelo B. Cavalcante, Derek M. Huffman, Darlene Berryman, Ed List, Yuji Ikeno, Nicolas Musi, Andrzej Bartke, John Kopchick, James L. Kirkland, Tamara Tchkonia, Michal M. Masternak

Research output: Contribution to journalReview article

Abstract

Growth hormone (GH) is secreted by the anterior pituitary gland and regulates various metabolic processes throughout the body. GH and IGF-1 levels are markedly reduced in older humans, leading some to hypothesize GH supplementation could be a viable “anti-aging” therapy. However, there is still much debate over the benefits and risks of GH administration. While an early study of GH administration reported reduced adiposity and lipid levels and increased bone mineral density, subsequent studies failed to show significant benefits. Conversely, other studies found positive effects of GH deficiency including extended life span, improved cognitive function, resistance to diseases such as cancer and diabetes, and improved insulin sensitivity despite a higher fat percentage. Thus, the roles of GH in aging and cognition remain unclear, and there is currently not enough evidence to support use of GH as an anti-aging or cognitive impairment therapy. Additional robust and longer-duration studies of efficacy and safety of GH administration are needed to determine if modulating GH levels could be a successful strategy for treating aging and age-related diseases.

Original languageEnglish (US)
JournalGeroScience
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Cognition
Growth Hormone
Anterior Pituitary Gland
Disease Resistance
Adiposity
Cognitive Therapy
Insulin-Like Growth Factor I
Bone Density
Insulin Resistance
Fats
Lipids
Safety

Keywords

  • Aging
  • Cognition
  • GH deficiency
  • Growth hormone
  • IGF-1
  • Longevity

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Cite this

Colon, G., Saccon, T., Schneider, A., Cavalcante, M. B., Huffman, D. M., Berryman, D., ... Masternak, M. M. (Accepted/In press). The enigmatic role of growth hormone in age-related diseases, cognition, and longevity. GeroScience. https://doi.org/10.1007/s11357-019-00096-w

The enigmatic role of growth hormone in age-related diseases, cognition, and longevity. / Colon, Gabriela; Saccon, Tatiana; Schneider, Augusto; Cavalcante, Marcelo B.; Huffman, Derek M.; Berryman, Darlene; List, Ed; Ikeno, Yuji; Musi, Nicolas; Bartke, Andrzej; Kopchick, John; Kirkland, James L.; Tchkonia, Tamara; Masternak, Michal M.

In: GeroScience, 01.01.2019.

Research output: Contribution to journalReview article

Colon, G, Saccon, T, Schneider, A, Cavalcante, MB, Huffman, DM, Berryman, D, List, E, Ikeno, Y, Musi, N, Bartke, A, Kopchick, J, Kirkland, JL, Tchkonia, T & Masternak, MM 2019, 'The enigmatic role of growth hormone in age-related diseases, cognition, and longevity', GeroScience. https://doi.org/10.1007/s11357-019-00096-w
Colon, Gabriela ; Saccon, Tatiana ; Schneider, Augusto ; Cavalcante, Marcelo B. ; Huffman, Derek M. ; Berryman, Darlene ; List, Ed ; Ikeno, Yuji ; Musi, Nicolas ; Bartke, Andrzej ; Kopchick, John ; Kirkland, James L. ; Tchkonia, Tamara ; Masternak, Michal M. / The enigmatic role of growth hormone in age-related diseases, cognition, and longevity. In: GeroScience. 2019.
@article{9cab6957505f41e5a403283cc84ea7a6,
title = "The enigmatic role of growth hormone in age-related diseases, cognition, and longevity",
abstract = "Growth hormone (GH) is secreted by the anterior pituitary gland and regulates various metabolic processes throughout the body. GH and IGF-1 levels are markedly reduced in older humans, leading some to hypothesize GH supplementation could be a viable “anti-aging” therapy. However, there is still much debate over the benefits and risks of GH administration. While an early study of GH administration reported reduced adiposity and lipid levels and increased bone mineral density, subsequent studies failed to show significant benefits. Conversely, other studies found positive effects of GH deficiency including extended life span, improved cognitive function, resistance to diseases such as cancer and diabetes, and improved insulin sensitivity despite a higher fat percentage. Thus, the roles of GH in aging and cognition remain unclear, and there is currently not enough evidence to support use of GH as an anti-aging or cognitive impairment therapy. Additional robust and longer-duration studies of efficacy and safety of GH administration are needed to determine if modulating GH levels could be a successful strategy for treating aging and age-related diseases.",
keywords = "Aging, Cognition, GH deficiency, Growth hormone, IGF-1, Longevity",
author = "Gabriela Colon and Tatiana Saccon and Augusto Schneider and Cavalcante, {Marcelo B.} and Huffman, {Derek M.} and Darlene Berryman and Ed List and Yuji Ikeno and Nicolas Musi and Andrzej Bartke and John Kopchick and Kirkland, {James L.} and Tamara Tchkonia and Masternak, {Michal M.}",
year = "2019",
month = "1",
day = "1",
doi = "10.1007/s11357-019-00096-w",
language = "English (US)",
journal = "GeroScience",
issn = "2509-2715",
publisher = "Springer International Publishing AG",

}

TY - JOUR

T1 - The enigmatic role of growth hormone in age-related diseases, cognition, and longevity

AU - Colon, Gabriela

AU - Saccon, Tatiana

AU - Schneider, Augusto

AU - Cavalcante, Marcelo B.

AU - Huffman, Derek M.

AU - Berryman, Darlene

AU - List, Ed

AU - Ikeno, Yuji

AU - Musi, Nicolas

AU - Bartke, Andrzej

AU - Kopchick, John

AU - Kirkland, James L.

AU - Tchkonia, Tamara

AU - Masternak, Michal M.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Growth hormone (GH) is secreted by the anterior pituitary gland and regulates various metabolic processes throughout the body. GH and IGF-1 levels are markedly reduced in older humans, leading some to hypothesize GH supplementation could be a viable “anti-aging” therapy. However, there is still much debate over the benefits and risks of GH administration. While an early study of GH administration reported reduced adiposity and lipid levels and increased bone mineral density, subsequent studies failed to show significant benefits. Conversely, other studies found positive effects of GH deficiency including extended life span, improved cognitive function, resistance to diseases such as cancer and diabetes, and improved insulin sensitivity despite a higher fat percentage. Thus, the roles of GH in aging and cognition remain unclear, and there is currently not enough evidence to support use of GH as an anti-aging or cognitive impairment therapy. Additional robust and longer-duration studies of efficacy and safety of GH administration are needed to determine if modulating GH levels could be a successful strategy for treating aging and age-related diseases.

AB - Growth hormone (GH) is secreted by the anterior pituitary gland and regulates various metabolic processes throughout the body. GH and IGF-1 levels are markedly reduced in older humans, leading some to hypothesize GH supplementation could be a viable “anti-aging” therapy. However, there is still much debate over the benefits and risks of GH administration. While an early study of GH administration reported reduced adiposity and lipid levels and increased bone mineral density, subsequent studies failed to show significant benefits. Conversely, other studies found positive effects of GH deficiency including extended life span, improved cognitive function, resistance to diseases such as cancer and diabetes, and improved insulin sensitivity despite a higher fat percentage. Thus, the roles of GH in aging and cognition remain unclear, and there is currently not enough evidence to support use of GH as an anti-aging or cognitive impairment therapy. Additional robust and longer-duration studies of efficacy and safety of GH administration are needed to determine if modulating GH levels could be a successful strategy for treating aging and age-related diseases.

KW - Aging

KW - Cognition

KW - GH deficiency

KW - Growth hormone

KW - IGF-1

KW - Longevity

UR - http://www.scopus.com/inward/record.url?scp=85072219925&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85072219925&partnerID=8YFLogxK

U2 - 10.1007/s11357-019-00096-w

DO - 10.1007/s11357-019-00096-w

M3 - Review article

JO - GeroScience

JF - GeroScience

SN - 2509-2715

ER -