TY - JOUR
T1 - The emerging science of Glioception
T2 - Contribution of glia in sensing, transduction, circuit integration of interoception
AU - Fabbri, Roberta
AU - Spennato, Diletta
AU - Conte, Giorgia
AU - Konstantoulaki, Aikaterini
AU - Lazzarini, Chiara
AU - Saracino, Emanuela
AU - Nicchia, Grazia Paola
AU - Frigeri, Antonio
AU - Zamboni, Roberto
AU - Spray, David C.
AU - Benfenati, Valentina
N1 - Publisher Copyright:
© 2023
PY - 2023/5
Y1 - 2023/5
N2 - Interoception is the process by which the nervous system regulates internal functions to achieve homeostasis. The role of neurons in interoception has received considerable recent attention, but glial cells also contribute. Glial cells can sense and transduce signals including osmotic, chemical, and mechanical status of extracellular milieu. Their ability to dynamically communicate “listening” and “talking” to neurons is necessary to monitor and regulate homeostasis and information integration in the nervous system. This review introduces the concept of “Glioception” and focuses on the process by which glial cells sense, interpret and integrate information about the inner state of the organism. Glial cells are ideally positioned to act as sensors and integrators of diverse interoceptive signals and can trigger regulatory responses via modulation of the activity of neuronal networks, both in physiological and pathological conditions. We believe that understanding and manipulating glioceptive processes and underlying molecular mechanisms provide a key path to develop new therapies for the prevention and alleviation of devastating interoceptive dysfunctions, among which pain is emphasized here with more focused details.
AB - Interoception is the process by which the nervous system regulates internal functions to achieve homeostasis. The role of neurons in interoception has received considerable recent attention, but glial cells also contribute. Glial cells can sense and transduce signals including osmotic, chemical, and mechanical status of extracellular milieu. Their ability to dynamically communicate “listening” and “talking” to neurons is necessary to monitor and regulate homeostasis and information integration in the nervous system. This review introduces the concept of “Glioception” and focuses on the process by which glial cells sense, interpret and integrate information about the inner state of the organism. Glial cells are ideally positioned to act as sensors and integrators of diverse interoceptive signals and can trigger regulatory responses via modulation of the activity of neuronal networks, both in physiological and pathological conditions. We believe that understanding and manipulating glioceptive processes and underlying molecular mechanisms provide a key path to develop new therapies for the prevention and alleviation of devastating interoceptive dysfunctions, among which pain is emphasized here with more focused details.
KW - AQPs
KW - Astrocytes
KW - Glia
KW - Glioception
KW - Interoception
KW - Pain
KW - TRPV
UR - http://www.scopus.com/inward/record.url?scp=85152744854&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85152744854&partnerID=8YFLogxK
U2 - 10.1016/j.pharmthera.2023.108403
DO - 10.1016/j.pharmthera.2023.108403
M3 - Review article
C2 - 37024060
AN - SCOPUS:85152744854
SN - 0163-7258
VL - 245
JO - Pharmacology and Therapeutics
JF - Pharmacology and Therapeutics
M1 - 108403
ER -