TY - JOUR
T1 - The emerging field of epigenetics in neurodegeneration and neuroprotection
AU - Hwang, Jee Yeon
AU - Aromolaran, Kelly A.
AU - Zukin, R. Suzanne
PY - 2017/6/1
Y1 - 2017/6/1
N2 - Epigenetic mechanisms-including DNA methylation, histone post-translational modifications and changes in nucleosome positioning-regulate gene expression, cellular differentiation and development in almost all tissues, including the brain. In adulthood, changes in the epigenome are crucial for higher cognitive functions such as learning and memory. Striking new evidence implicates the dysregulation of epigenetic mechanisms in neurodegenerative disorders and diseases. Although these disorders differ in their underlying causes and pathophysiologies, many involve the dysregulation of restrictive element 1-silencing transcription factor (REST), which acts via epigenetic mechanisms to regulate gene expression. Although not somatically heritable, epigenetic modifications in neurons are dynamic and reversible, which makes them good targets for therapeutic intervention.
AB - Epigenetic mechanisms-including DNA methylation, histone post-translational modifications and changes in nucleosome positioning-regulate gene expression, cellular differentiation and development in almost all tissues, including the brain. In adulthood, changes in the epigenome are crucial for higher cognitive functions such as learning and memory. Striking new evidence implicates the dysregulation of epigenetic mechanisms in neurodegenerative disorders and diseases. Although these disorders differ in their underlying causes and pathophysiologies, many involve the dysregulation of restrictive element 1-silencing transcription factor (REST), which acts via epigenetic mechanisms to regulate gene expression. Although not somatically heritable, epigenetic modifications in neurons are dynamic and reversible, which makes them good targets for therapeutic intervention.
UR - http://www.scopus.com/inward/record.url?scp=85019360968&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85019360968&partnerID=8YFLogxK
U2 - 10.1038/nrn.2017.46
DO - 10.1038/nrn.2017.46
M3 - Review article
C2 - 28515491
AN - SCOPUS:85019360968
SN - 1471-003X
VL - 18
SP - 347
EP - 361
JO - Nature Reviews Neuroscience
JF - Nature Reviews Neuroscience
IS - 6
ER -