The emerging field of epigenetics in neurodegeneration and neuroprotection

Jee Yeon Hwang, Kelly A. Aromolaran, R. Suzanne Zukin

Research output: Contribution to journalReview article

84 Scopus citations

Abstract

Epigenetic mechanisms-including DNA methylation, histone post-translational modifications and changes in nucleosome positioning-regulate gene expression, cellular differentiation and development in almost all tissues, including the brain. In adulthood, changes in the epigenome are crucial for higher cognitive functions such as learning and memory. Striking new evidence implicates the dysregulation of epigenetic mechanisms in neurodegenerative disorders and diseases. Although these disorders differ in their underlying causes and pathophysiologies, many involve the dysregulation of restrictive element 1-silencing transcription factor (REST), which acts via epigenetic mechanisms to regulate gene expression. Although not somatically heritable, epigenetic modifications in neurons are dynamic and reversible, which makes them good targets for therapeutic intervention.

Original languageEnglish (US)
Pages (from-to)347-361
Number of pages15
JournalNature Reviews Neuroscience
Volume18
Issue number6
DOIs
StatePublished - Jun 1 2017

ASJC Scopus subject areas

  • Neuroscience(all)

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