The effects of preoperative chemotherapy on the resectability of non-small cell lung carcinoma with mediastinal lymph node metastases (N2 M0)

Nael Martini, Mark G. Kris, Richard J. Gralla, Manjit S. Bains, Patricia M. McCormack, Larry R. Kaiser, Michael E. Burt, Muhammad B. Zaman

Research output: Contribution to journalArticle

135 Citations (Scopus)

Abstract

We have defined "clinical N2" disease in non-small cell lung cancer to mean the presence of enlarged metastatic mediastinal nodes evident on plain chest roentgenograms or widening of the carina at bronchoscopy. Forty-one patients with non-small cell carcinoma of the lung and clinical N2 M0 disease presumed operable received 2 to 3 cycles of high-dose cisplatin with vindesine (or vinblastine sulfate) with or without mitomycin-C. Following chemotherapy, 30 patients (73%) had a major radiographic response. Of these patients, 28 had thoracotomy, and 21 (75%) of them had complete resection of the disease, 8 of whom had total sterilization of the tumor proven histologically. An additional 4 patients had limited microscopic foci of residual tumor either in lung or lymph nodes. Survival at 3 years from diagnosis was 34% for all patients, 40% for those who completed the combined treatment (chemotherapy and surgery), and 54% for those who had complete resection with a median follow-up of 44 months and a median survival not yeat attained.

Original languageEnglish (US)
Pages (from-to)370-379
Number of pages10
JournalThe Annals of thoracic surgery
Volume45
Issue number4
StatePublished - Apr 1988
Externally publishedYes

Fingerprint

Non-Small Cell Lung Carcinoma
Lymph Nodes
Neoplasm Metastasis
Drug Therapy
Vindesine
Survival
Vinblastine
Residual Neoplasm
Mitomycin
Bronchoscopy
Thoracotomy
Cisplatin
Thorax
Lung
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Surgery
  • Cardiology and Cardiovascular Medicine

Cite this

Martini, N., Kris, M. G., Gralla, R. J., Bains, M. S., McCormack, P. M., Kaiser, L. R., ... Zaman, M. B. (1988). The effects of preoperative chemotherapy on the resectability of non-small cell lung carcinoma with mediastinal lymph node metastases (N2 M0). The Annals of thoracic surgery, 45(4), 370-379.

The effects of preoperative chemotherapy on the resectability of non-small cell lung carcinoma with mediastinal lymph node metastases (N2 M0). / Martini, Nael; Kris, Mark G.; Gralla, Richard J.; Bains, Manjit S.; McCormack, Patricia M.; Kaiser, Larry R.; Burt, Michael E.; Zaman, Muhammad B.

In: The Annals of thoracic surgery, Vol. 45, No. 4, 04.1988, p. 370-379.

Research output: Contribution to journalArticle

Martini, N, Kris, MG, Gralla, RJ, Bains, MS, McCormack, PM, Kaiser, LR, Burt, ME & Zaman, MB 1988, 'The effects of preoperative chemotherapy on the resectability of non-small cell lung carcinoma with mediastinal lymph node metastases (N2 M0)', The Annals of thoracic surgery, vol. 45, no. 4, pp. 370-379.
Martini, Nael ; Kris, Mark G. ; Gralla, Richard J. ; Bains, Manjit S. ; McCormack, Patricia M. ; Kaiser, Larry R. ; Burt, Michael E. ; Zaman, Muhammad B. / The effects of preoperative chemotherapy on the resectability of non-small cell lung carcinoma with mediastinal lymph node metastases (N2 M0). In: The Annals of thoracic surgery. 1988 ; Vol. 45, No. 4. pp. 370-379.
@article{3a6662913d1b462195e6771c6c6bd618,
title = "The effects of preoperative chemotherapy on the resectability of non-small cell lung carcinoma with mediastinal lymph node metastases (N2 M0)",
abstract = "We have defined {"}clinical N2{"} disease in non-small cell lung cancer to mean the presence of enlarged metastatic mediastinal nodes evident on plain chest roentgenograms or widening of the carina at bronchoscopy. Forty-one patients with non-small cell carcinoma of the lung and clinical N2 M0 disease presumed operable received 2 to 3 cycles of high-dose cisplatin with vindesine (or vinblastine sulfate) with or without mitomycin-C. Following chemotherapy, 30 patients (73{\%}) had a major radiographic response. Of these patients, 28 had thoracotomy, and 21 (75{\%}) of them had complete resection of the disease, 8 of whom had total sterilization of the tumor proven histologically. An additional 4 patients had limited microscopic foci of residual tumor either in lung or lymph nodes. Survival at 3 years from diagnosis was 34{\%} for all patients, 40{\%} for those who completed the combined treatment (chemotherapy and surgery), and 54{\%} for those who had complete resection with a median follow-up of 44 months and a median survival not yeat attained.",
author = "Nael Martini and Kris, {Mark G.} and Gralla, {Richard J.} and Bains, {Manjit S.} and McCormack, {Patricia M.} and Kaiser, {Larry R.} and Burt, {Michael E.} and Zaman, {Muhammad B.}",
year = "1988",
month = "4",
language = "English (US)",
volume = "45",
pages = "370--379",
journal = "Annals of Thoracic Surgery",
issn = "0003-4975",
publisher = "Elsevier USA",
number = "4",

}

TY - JOUR

T1 - The effects of preoperative chemotherapy on the resectability of non-small cell lung carcinoma with mediastinal lymph node metastases (N2 M0)

AU - Martini, Nael

AU - Kris, Mark G.

AU - Gralla, Richard J.

AU - Bains, Manjit S.

AU - McCormack, Patricia M.

AU - Kaiser, Larry R.

AU - Burt, Michael E.

AU - Zaman, Muhammad B.

PY - 1988/4

Y1 - 1988/4

N2 - We have defined "clinical N2" disease in non-small cell lung cancer to mean the presence of enlarged metastatic mediastinal nodes evident on plain chest roentgenograms or widening of the carina at bronchoscopy. Forty-one patients with non-small cell carcinoma of the lung and clinical N2 M0 disease presumed operable received 2 to 3 cycles of high-dose cisplatin with vindesine (or vinblastine sulfate) with or without mitomycin-C. Following chemotherapy, 30 patients (73%) had a major radiographic response. Of these patients, 28 had thoracotomy, and 21 (75%) of them had complete resection of the disease, 8 of whom had total sterilization of the tumor proven histologically. An additional 4 patients had limited microscopic foci of residual tumor either in lung or lymph nodes. Survival at 3 years from diagnosis was 34% for all patients, 40% for those who completed the combined treatment (chemotherapy and surgery), and 54% for those who had complete resection with a median follow-up of 44 months and a median survival not yeat attained.

AB - We have defined "clinical N2" disease in non-small cell lung cancer to mean the presence of enlarged metastatic mediastinal nodes evident on plain chest roentgenograms or widening of the carina at bronchoscopy. Forty-one patients with non-small cell carcinoma of the lung and clinical N2 M0 disease presumed operable received 2 to 3 cycles of high-dose cisplatin with vindesine (or vinblastine sulfate) with or without mitomycin-C. Following chemotherapy, 30 patients (73%) had a major radiographic response. Of these patients, 28 had thoracotomy, and 21 (75%) of them had complete resection of the disease, 8 of whom had total sterilization of the tumor proven histologically. An additional 4 patients had limited microscopic foci of residual tumor either in lung or lymph nodes. Survival at 3 years from diagnosis was 34% for all patients, 40% for those who completed the combined treatment (chemotherapy and surgery), and 54% for those who had complete resection with a median follow-up of 44 months and a median survival not yeat attained.

UR - http://www.scopus.com/inward/record.url?scp=0023949121&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023949121&partnerID=8YFLogxK

M3 - Article

C2 - 2833188

AN - SCOPUS:0023949121

VL - 45

SP - 370

EP - 379

JO - Annals of Thoracic Surgery

JF - Annals of Thoracic Surgery

SN - 0003-4975

IS - 4

ER -