The effects of intrathecal sympathomimetic agents on neural activity in the lumbar sympathetic chain of rats

Richard M. LoPachin, Thomas A. Rudy

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Intrathecal injections of norepinephrine (0.30 μmol) and clonidine (0.035 μmol) produced decreases in neural activity recorded from the lumbar sympathetic chain and caused changes in rat thermoregulation consistent with a reduction in efferent sympathetic activity. These results support the conclusion that bulbospinal noradrenergic pathways inhibit sympathetic outflow. The data also indicate that the spinal cord is a potential site of action for clonidine.

Original languageEnglish (US)
Pages (from-to)195-198
Number of pages4
JournalBrain Research
Volume224
Issue number1
DOIs
StatePublished - Nov 9 1981
Externally publishedYes

Fingerprint

Sympathomimetics
Clonidine
Spinal Injections
Body Temperature Regulation
Action Potentials
Spinal Cord
Norepinephrine

Keywords

  • clonidine
  • intrathecal injections
  • norepinephrine
  • spinal cord
  • sympathetic activity
  • thermoregulation

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

The effects of intrathecal sympathomimetic agents on neural activity in the lumbar sympathetic chain of rats. / LoPachin, Richard M.; Rudy, Thomas A.

In: Brain Research, Vol. 224, No. 1, 09.11.1981, p. 195-198.

Research output: Contribution to journalArticle

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