The effects of intrathecal sympathomimetic agents on neural activity in the lumbar sympathetic chain of rats

Richard M. LoPachin; Thomas A. Rudy

doi:10.1016/0006-8993(81)91132-X

The effects of intrathecal sympathomimetic agents on neural activity in the lumbar sympathetic chain of rats

Richard M. LoPachin, Thomas A. Rudy

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Intrathecal injections of norepinephrine (0.30 μmol) and clonidine (0.035 μmol) produced decreases in neural activity recorded from the lumbar sympathetic chain and caused changes in rat thermoregulation consistent with a reduction in efferent sympathetic activity. These results support the conclusion that bulbospinal noradrenergic pathways inhibit sympathetic outflow. The data also indicate that the spinal cord is a potential site of action for clonidine.

Original language	English (US)
Pages (from-to)	195-198
Number of pages	4
Journal	Brain Research
Volume	224
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(81)91132-X
State	Published - Nov 9 1981
Externally published	Yes

Keywords

clonidine
intrathecal injections
norepinephrine
spinal cord
sympathetic activity
thermoregulation

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(81)91132-X

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AU - Rudy, Thomas A.

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N2 - Intrathecal injections of norepinephrine (0.30 μmol) and clonidine (0.035 μmol) produced decreases in neural activity recorded from the lumbar sympathetic chain and caused changes in rat thermoregulation consistent with a reduction in efferent sympathetic activity. These results support the conclusion that bulbospinal noradrenergic pathways inhibit sympathetic outflow. The data also indicate that the spinal cord is a potential site of action for clonidine.

AB - Intrathecal injections of norepinephrine (0.30 μmol) and clonidine (0.035 μmol) produced decreases in neural activity recorded from the lumbar sympathetic chain and caused changes in rat thermoregulation consistent with a reduction in efferent sympathetic activity. These results support the conclusion that bulbospinal noradrenergic pathways inhibit sympathetic outflow. The data also indicate that the spinal cord is a potential site of action for clonidine.

KW - clonidine

KW - intrathecal injections

KW - norepinephrine

KW - spinal cord

KW - sympathetic activity

KW - thermoregulation

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The effects of intrathecal sympathomimetic agents on neural activity in the lumbar sympathetic chain of rats

Abstract

Keywords

ASJC Scopus subject areas

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