The effects of intrathecal sympathomimetic agents on neural activity in the lumbar sympathetic chain of rats

Richard M. LoPachin, Thomas A. Rudy

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Intrathecal injections of norepinephrine (0.30 μmol) and clonidine (0.035 μmol) produced decreases in neural activity recorded from the lumbar sympathetic chain and caused changes in rat thermoregulation consistent with a reduction in efferent sympathetic activity. These results support the conclusion that bulbospinal noradrenergic pathways inhibit sympathetic outflow. The data also indicate that the spinal cord is a potential site of action for clonidine.

Original languageEnglish (US)
Pages (from-to)195-198
Number of pages4
JournalBrain Research
Volume224
Issue number1
DOIs
StatePublished - Nov 9 1981
Externally publishedYes

Keywords

  • clonidine
  • intrathecal injections
  • norepinephrine
  • spinal cord
  • sympathetic activity
  • thermoregulation

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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