The effects of interaction between familial and reproductive factors on breast cancer risk

A combined analysis of seven case-control studies

N. Andrieu, T. Smith, S. Duffy, D. G. Zaridze, R. Renaud, Thomas E. Rohan, M. Gerber, E. Luporsi, M. Lê, H. P. Lee, Y. Lifanova, N. E. Day

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

In this paper, a combined analysis was performed to study the interaction between familial risk and reproductive life factors. In particular, the interaction between familial risk and breast cell mitotic activity (BCMA), as assessed by duration of ovarian activity, was investigated because of the potential importance of mitotic activity on genetically susceptible cells. The present analysis included 3152 cases and 4404 controls in seven case-control studies from four countries. The interaction effect was estimated in each study separately, then combined using two different methods: a multivariate weighted average and a Bayesian random-effects model. The main effects of reproductive life factors on the risk of breast cancer were in agreement with the previous findings. In particular, an increased duration of BCMA before the first childbirth and over life was found to increase the risk of breast cancer (P < 0.001). Slightly increasing but nonsignificant, familial risks were observed with increasing number of children (P = 0.17), increasing age at first childbirth (P > 0.2) and increasing duration of BCMA (P > 0.2). There was no modification in familial risk with age at menarche and no clear pattern with menopause characteristics. A weak influence of reproductive and menstrual factors on the familial risk emerged from the present study.

Original languageEnglish (US)
Pages (from-to)1525-1536
Number of pages12
JournalBritish Journal of Cancer
Volume77
Issue number9
StatePublished - 1998
Externally publishedYes

Fingerprint

Case-Control Studies
Breast Neoplasms
Breast
Menarche
Menopause
Parturition

Keywords

  • Breast cancer
  • Familial risk
  • Interactions
  • Reproductive life factor

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

The effects of interaction between familial and reproductive factors on breast cancer risk : A combined analysis of seven case-control studies. / Andrieu, N.; Smith, T.; Duffy, S.; Zaridze, D. G.; Renaud, R.; Rohan, Thomas E.; Gerber, M.; Luporsi, E.; Lê, M.; Lee, H. P.; Lifanova, Y.; Day, N. E.

In: British Journal of Cancer, Vol. 77, No. 9, 1998, p. 1525-1536.

Research output: Contribution to journalArticle

Andrieu, N, Smith, T, Duffy, S, Zaridze, DG, Renaud, R, Rohan, TE, Gerber, M, Luporsi, E, Lê, M, Lee, HP, Lifanova, Y & Day, NE 1998, 'The effects of interaction between familial and reproductive factors on breast cancer risk: A combined analysis of seven case-control studies', British Journal of Cancer, vol. 77, no. 9, pp. 1525-1536.
Andrieu, N. ; Smith, T. ; Duffy, S. ; Zaridze, D. G. ; Renaud, R. ; Rohan, Thomas E. ; Gerber, M. ; Luporsi, E. ; Lê, M. ; Lee, H. P. ; Lifanova, Y. ; Day, N. E. / The effects of interaction between familial and reproductive factors on breast cancer risk : A combined analysis of seven case-control studies. In: British Journal of Cancer. 1998 ; Vol. 77, No. 9. pp. 1525-1536.
@article{13843b11630e471f9dab1a634b9c192a,
title = "The effects of interaction between familial and reproductive factors on breast cancer risk: A combined analysis of seven case-control studies",
abstract = "In this paper, a combined analysis was performed to study the interaction between familial risk and reproductive life factors. In particular, the interaction between familial risk and breast cell mitotic activity (BCMA), as assessed by duration of ovarian activity, was investigated because of the potential importance of mitotic activity on genetically susceptible cells. The present analysis included 3152 cases and 4404 controls in seven case-control studies from four countries. The interaction effect was estimated in each study separately, then combined using two different methods: a multivariate weighted average and a Bayesian random-effects model. The main effects of reproductive life factors on the risk of breast cancer were in agreement with the previous findings. In particular, an increased duration of BCMA before the first childbirth and over life was found to increase the risk of breast cancer (P < 0.001). Slightly increasing but nonsignificant, familial risks were observed with increasing number of children (P = 0.17), increasing age at first childbirth (P > 0.2) and increasing duration of BCMA (P > 0.2). There was no modification in familial risk with age at menarche and no clear pattern with menopause characteristics. A weak influence of reproductive and menstrual factors on the familial risk emerged from the present study.",
keywords = "Breast cancer, Familial risk, Interactions, Reproductive life factor",
author = "N. Andrieu and T. Smith and S. Duffy and Zaridze, {D. G.} and R. Renaud and Rohan, {Thomas E.} and M. Gerber and E. Luporsi and M. L{\^e} and Lee, {H. P.} and Y. Lifanova and Day, {N. E.}",
year = "1998",
language = "English (US)",
volume = "77",
pages = "1525--1536",
journal = "British Journal of Cancer",
issn = "0007-0920",
publisher = "Nature Publishing Group",
number = "9",

}

TY - JOUR

T1 - The effects of interaction between familial and reproductive factors on breast cancer risk

T2 - A combined analysis of seven case-control studies

AU - Andrieu, N.

AU - Smith, T.

AU - Duffy, S.

AU - Zaridze, D. G.

AU - Renaud, R.

AU - Rohan, Thomas E.

AU - Gerber, M.

AU - Luporsi, E.

AU - Lê, M.

AU - Lee, H. P.

AU - Lifanova, Y.

AU - Day, N. E.

PY - 1998

Y1 - 1998

N2 - In this paper, a combined analysis was performed to study the interaction between familial risk and reproductive life factors. In particular, the interaction between familial risk and breast cell mitotic activity (BCMA), as assessed by duration of ovarian activity, was investigated because of the potential importance of mitotic activity on genetically susceptible cells. The present analysis included 3152 cases and 4404 controls in seven case-control studies from four countries. The interaction effect was estimated in each study separately, then combined using two different methods: a multivariate weighted average and a Bayesian random-effects model. The main effects of reproductive life factors on the risk of breast cancer were in agreement with the previous findings. In particular, an increased duration of BCMA before the first childbirth and over life was found to increase the risk of breast cancer (P < 0.001). Slightly increasing but nonsignificant, familial risks were observed with increasing number of children (P = 0.17), increasing age at first childbirth (P > 0.2) and increasing duration of BCMA (P > 0.2). There was no modification in familial risk with age at menarche and no clear pattern with menopause characteristics. A weak influence of reproductive and menstrual factors on the familial risk emerged from the present study.

AB - In this paper, a combined analysis was performed to study the interaction between familial risk and reproductive life factors. In particular, the interaction between familial risk and breast cell mitotic activity (BCMA), as assessed by duration of ovarian activity, was investigated because of the potential importance of mitotic activity on genetically susceptible cells. The present analysis included 3152 cases and 4404 controls in seven case-control studies from four countries. The interaction effect was estimated in each study separately, then combined using two different methods: a multivariate weighted average and a Bayesian random-effects model. The main effects of reproductive life factors on the risk of breast cancer were in agreement with the previous findings. In particular, an increased duration of BCMA before the first childbirth and over life was found to increase the risk of breast cancer (P < 0.001). Slightly increasing but nonsignificant, familial risks were observed with increasing number of children (P = 0.17), increasing age at first childbirth (P > 0.2) and increasing duration of BCMA (P > 0.2). There was no modification in familial risk with age at menarche and no clear pattern with menopause characteristics. A weak influence of reproductive and menstrual factors on the familial risk emerged from the present study.

KW - Breast cancer

KW - Familial risk

KW - Interactions

KW - Reproductive life factor

UR - http://www.scopus.com/inward/record.url?scp=7144263748&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=7144263748&partnerID=8YFLogxK

M3 - Article

VL - 77

SP - 1525

EP - 1536

JO - British Journal of Cancer

JF - British Journal of Cancer

SN - 0007-0920

IS - 9

ER -