The effects of hypertension on the paediatric brain: A justifiable concern

Madhu Sharma, Juan C. Kupferman, Yuri Brosgol, Kara Paterno, Sharon Goodman, Isak Prohovnik, Fenella J. Kirkham, Steven G. Pavlakis

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The prevalence of hypertension in children is increasing but its neurological effects are under-recognised. Here, we describe acute and chronic effects of childhood hypertension on the nervous system. Acute neurological involvement ranges from posterior reversible encephalopathy syndrome to, possibly, infarction and haemorrhage. Children with chronic hypertension are likely to have learning disabilities and deficiencies in executive function, which are potentially reversible with antihypertensive treatment. These cognitive defects may be secondary to abnormal regulation of cerebral blood flow. Raised blood pressure in childhood could also contribute to the early development of atherosclerosis, which can have both short-term and long-term adverse effects on vasculature. Clinical studies are needed to better define the full clinical range of paediatric hypertension on a child's nervous system. Furthermore, accurate biomarkers to define cognitive abnormalities and cerebral involvement need to be identified.

Original languageEnglish (US)
Pages (from-to)933-940
Number of pages8
JournalThe Lancet Neurology
Volume9
Issue number9
DOIs
StatePublished - Sep 2010
Externally publishedYes

Fingerprint

Pediatrics
Hypertension
Brain
Nervous System
Cerebrovascular Circulation
Posterior Leukoencephalopathy Syndrome
Learning Disorders
Executive Function
Infarction
Antihypertensive Agents
Atherosclerosis
Biomarkers
Hemorrhage
Blood Pressure
Therapeutics
Clinical Studies
Long Term Adverse Effects

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Sharma, M., Kupferman, J. C., Brosgol, Y., Paterno, K., Goodman, S., Prohovnik, I., ... Pavlakis, S. G. (2010). The effects of hypertension on the paediatric brain: A justifiable concern. The Lancet Neurology, 9(9), 933-940. https://doi.org/10.1016/S1474-4422(10)70167-8

The effects of hypertension on the paediatric brain : A justifiable concern. / Sharma, Madhu; Kupferman, Juan C.; Brosgol, Yuri; Paterno, Kara; Goodman, Sharon; Prohovnik, Isak; Kirkham, Fenella J.; Pavlakis, Steven G.

In: The Lancet Neurology, Vol. 9, No. 9, 09.2010, p. 933-940.

Research output: Contribution to journalArticle

Sharma, M, Kupferman, JC, Brosgol, Y, Paterno, K, Goodman, S, Prohovnik, I, Kirkham, FJ & Pavlakis, SG 2010, 'The effects of hypertension on the paediatric brain: A justifiable concern', The Lancet Neurology, vol. 9, no. 9, pp. 933-940. https://doi.org/10.1016/S1474-4422(10)70167-8
Sharma, Madhu ; Kupferman, Juan C. ; Brosgol, Yuri ; Paterno, Kara ; Goodman, Sharon ; Prohovnik, Isak ; Kirkham, Fenella J. ; Pavlakis, Steven G. / The effects of hypertension on the paediatric brain : A justifiable concern. In: The Lancet Neurology. 2010 ; Vol. 9, No. 9. pp. 933-940.
@article{8ba09f9ff1104f379e882bc67c2129df,
title = "The effects of hypertension on the paediatric brain: A justifiable concern",
abstract = "The prevalence of hypertension in children is increasing but its neurological effects are under-recognised. Here, we describe acute and chronic effects of childhood hypertension on the nervous system. Acute neurological involvement ranges from posterior reversible encephalopathy syndrome to, possibly, infarction and haemorrhage. Children with chronic hypertension are likely to have learning disabilities and deficiencies in executive function, which are potentially reversible with antihypertensive treatment. These cognitive defects may be secondary to abnormal regulation of cerebral blood flow. Raised blood pressure in childhood could also contribute to the early development of atherosclerosis, which can have both short-term and long-term adverse effects on vasculature. Clinical studies are needed to better define the full clinical range of paediatric hypertension on a child's nervous system. Furthermore, accurate biomarkers to define cognitive abnormalities and cerebral involvement need to be identified.",
author = "Madhu Sharma and Kupferman, {Juan C.} and Yuri Brosgol and Kara Paterno and Sharon Goodman and Isak Prohovnik and Kirkham, {Fenella J.} and Pavlakis, {Steven G.}",
year = "2010",
month = "9",
doi = "10.1016/S1474-4422(10)70167-8",
language = "English (US)",
volume = "9",
pages = "933--940",
journal = "The Lancet Neurology",
issn = "1474-4422",
publisher = "Lancet Publishing Group",
number = "9",

}

TY - JOUR

T1 - The effects of hypertension on the paediatric brain

T2 - A justifiable concern

AU - Sharma, Madhu

AU - Kupferman, Juan C.

AU - Brosgol, Yuri

AU - Paterno, Kara

AU - Goodman, Sharon

AU - Prohovnik, Isak

AU - Kirkham, Fenella J.

AU - Pavlakis, Steven G.

PY - 2010/9

Y1 - 2010/9

N2 - The prevalence of hypertension in children is increasing but its neurological effects are under-recognised. Here, we describe acute and chronic effects of childhood hypertension on the nervous system. Acute neurological involvement ranges from posterior reversible encephalopathy syndrome to, possibly, infarction and haemorrhage. Children with chronic hypertension are likely to have learning disabilities and deficiencies in executive function, which are potentially reversible with antihypertensive treatment. These cognitive defects may be secondary to abnormal regulation of cerebral blood flow. Raised blood pressure in childhood could also contribute to the early development of atherosclerosis, which can have both short-term and long-term adverse effects on vasculature. Clinical studies are needed to better define the full clinical range of paediatric hypertension on a child's nervous system. Furthermore, accurate biomarkers to define cognitive abnormalities and cerebral involvement need to be identified.

AB - The prevalence of hypertension in children is increasing but its neurological effects are under-recognised. Here, we describe acute and chronic effects of childhood hypertension on the nervous system. Acute neurological involvement ranges from posterior reversible encephalopathy syndrome to, possibly, infarction and haemorrhage. Children with chronic hypertension are likely to have learning disabilities and deficiencies in executive function, which are potentially reversible with antihypertensive treatment. These cognitive defects may be secondary to abnormal regulation of cerebral blood flow. Raised blood pressure in childhood could also contribute to the early development of atherosclerosis, which can have both short-term and long-term adverse effects on vasculature. Clinical studies are needed to better define the full clinical range of paediatric hypertension on a child's nervous system. Furthermore, accurate biomarkers to define cognitive abnormalities and cerebral involvement need to be identified.

UR - http://www.scopus.com/inward/record.url?scp=77955662357&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77955662357&partnerID=8YFLogxK

U2 - 10.1016/S1474-4422(10)70167-8

DO - 10.1016/S1474-4422(10)70167-8

M3 - Article

C2 - 20675195

AN - SCOPUS:77955662357

VL - 9

SP - 933

EP - 940

JO - The Lancet Neurology

JF - The Lancet Neurology

SN - 1474-4422

IS - 9

ER -