The Effects of Dairy Intake on Insulin Resistance: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Kristen M. Sochol, Tanya S. Johns, Rupinder S. Buttar, Lovepreet Randhawa, Edeline Sanchez, Maya Gal, Katherine Lestrade, Massini Merzkani, Matthew K. Abramowitz, Yasmin Mossavar-Rahmani, Michal L. Melamed

Research output: Contribution to journalArticle

Abstract

The incidence of type 2 diabetes mellitus (DM) has increased in the US over the last several years. The consumption of low-fat dairy foods has been linked with decreasing the risk of DM but studies have yet to show a clear correlation. We conducted a systematic review and meta-analysis of randomized clinical trials (RCTs) evaluating the effects of dairy intake on homeostatic model assessment of insulin resistance (HOMA-IR), waist circumference, and body weight. In MEDLINE and Embase, we identified and reviewed 49 relevant RCTs: 30 had appropriate data format for inclusion in the meta-analysis. Using the Review Manager 5 software, we calculated the pooled standardized mean differences comparing dairy dietary interventions to control for our outcomes of interest. For HOMA-IR (794 individuals), we found a mean difference of -1.21 (95% CI -1.74 to -0.67; p-value < 0.00001; I2 = 92%). For waist circumference (1348 individuals), the mean difference was -1.09 cm (95% CI 1.68 to -0.58; p-value < 0.00001; I2 = 94%). For body weight (2362 individuals), the dairy intake intervention group weighed 0.42 kg less than control (p-value < 0.00001; I2 = 92%). Our findings suggest that dairy intake, especially low-fat dairy products, has a beneficial effect on HOMA-IR, waist circumference, and body weight. This could impact dietary recommendations to reduce DM risk.

Original languageEnglish (US)
JournalNutrients
Volume11
Issue number9
DOIs
StatePublished - Sep 17 2019

Fingerprint

dairy consumption
randomized clinical trials
waist circumference
systematic review
Waist Circumference
meta-analysis
insulin resistance
Insulin Resistance
Meta-Analysis
Randomized Controlled Trials
Body Weight
diabetes mellitus
body weight
Diabetes Mellitus
low fat dairy products
Fats
Dairy Products
dietary recommendations
noninsulin-dependent diabetes mellitus
Individuality

Keywords

  • dairy intake
  • diet
  • insulin resistance
  • low-fat dairy
  • waist circumference
  • weight loss

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this

The Effects of Dairy Intake on Insulin Resistance : A Systematic Review and Meta-Analysis of Randomized Clinical Trials. / Sochol, Kristen M.; Johns, Tanya S.; Buttar, Rupinder S.; Randhawa, Lovepreet; Sanchez, Edeline; Gal, Maya; Lestrade, Katherine; Merzkani, Massini; Abramowitz, Matthew K.; Mossavar-Rahmani, Yasmin; Melamed, Michal L.

In: Nutrients, Vol. 11, No. 9, 17.09.2019.

Research output: Contribution to journalArticle

Sochol, Kristen M. ; Johns, Tanya S. ; Buttar, Rupinder S. ; Randhawa, Lovepreet ; Sanchez, Edeline ; Gal, Maya ; Lestrade, Katherine ; Merzkani, Massini ; Abramowitz, Matthew K. ; Mossavar-Rahmani, Yasmin ; Melamed, Michal L. / The Effects of Dairy Intake on Insulin Resistance : A Systematic Review and Meta-Analysis of Randomized Clinical Trials. In: Nutrients. 2019 ; Vol. 11, No. 9.
@article{920d5b5acb6e4d358a1d810dc8609459,
title = "The Effects of Dairy Intake on Insulin Resistance: A Systematic Review and Meta-Analysis of Randomized Clinical Trials",
abstract = "The incidence of type 2 diabetes mellitus (DM) has increased in the US over the last several years. The consumption of low-fat dairy foods has been linked with decreasing the risk of DM but studies have yet to show a clear correlation. We conducted a systematic review and meta-analysis of randomized clinical trials (RCTs) evaluating the effects of dairy intake on homeostatic model assessment of insulin resistance (HOMA-IR), waist circumference, and body weight. In MEDLINE and Embase, we identified and reviewed 49 relevant RCTs: 30 had appropriate data format for inclusion in the meta-analysis. Using the Review Manager 5 software, we calculated the pooled standardized mean differences comparing dairy dietary interventions to control for our outcomes of interest. For HOMA-IR (794 individuals), we found a mean difference of -1.21 (95{\%} CI -1.74 to -0.67; p-value < 0.00001; I2 = 92{\%}). For waist circumference (1348 individuals), the mean difference was -1.09 cm (95{\%} CI 1.68 to -0.58; p-value < 0.00001; I2 = 94{\%}). For body weight (2362 individuals), the dairy intake intervention group weighed 0.42 kg less than control (p-value < 0.00001; I2 = 92{\%}). Our findings suggest that dairy intake, especially low-fat dairy products, has a beneficial effect on HOMA-IR, waist circumference, and body weight. This could impact dietary recommendations to reduce DM risk.",
keywords = "dairy intake, diet, insulin resistance, low-fat dairy, waist circumference, weight loss",
author = "Sochol, {Kristen M.} and Johns, {Tanya S.} and Buttar, {Rupinder S.} and Lovepreet Randhawa and Edeline Sanchez and Maya Gal and Katherine Lestrade and Massini Merzkani and Abramowitz, {Matthew K.} and Yasmin Mossavar-Rahmani and Melamed, {Michal L.}",
year = "2019",
month = "9",
day = "17",
doi = "10.3390/nu11092237",
language = "English (US)",
volume = "11",
journal = "Nutrients",
issn = "2072-6643",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "9",

}

TY - JOUR

T1 - The Effects of Dairy Intake on Insulin Resistance

T2 - A Systematic Review and Meta-Analysis of Randomized Clinical Trials

AU - Sochol, Kristen M.

AU - Johns, Tanya S.

AU - Buttar, Rupinder S.

AU - Randhawa, Lovepreet

AU - Sanchez, Edeline

AU - Gal, Maya

AU - Lestrade, Katherine

AU - Merzkani, Massini

AU - Abramowitz, Matthew K.

AU - Mossavar-Rahmani, Yasmin

AU - Melamed, Michal L.

PY - 2019/9/17

Y1 - 2019/9/17

N2 - The incidence of type 2 diabetes mellitus (DM) has increased in the US over the last several years. The consumption of low-fat dairy foods has been linked with decreasing the risk of DM but studies have yet to show a clear correlation. We conducted a systematic review and meta-analysis of randomized clinical trials (RCTs) evaluating the effects of dairy intake on homeostatic model assessment of insulin resistance (HOMA-IR), waist circumference, and body weight. In MEDLINE and Embase, we identified and reviewed 49 relevant RCTs: 30 had appropriate data format for inclusion in the meta-analysis. Using the Review Manager 5 software, we calculated the pooled standardized mean differences comparing dairy dietary interventions to control for our outcomes of interest. For HOMA-IR (794 individuals), we found a mean difference of -1.21 (95% CI -1.74 to -0.67; p-value < 0.00001; I2 = 92%). For waist circumference (1348 individuals), the mean difference was -1.09 cm (95% CI 1.68 to -0.58; p-value < 0.00001; I2 = 94%). For body weight (2362 individuals), the dairy intake intervention group weighed 0.42 kg less than control (p-value < 0.00001; I2 = 92%). Our findings suggest that dairy intake, especially low-fat dairy products, has a beneficial effect on HOMA-IR, waist circumference, and body weight. This could impact dietary recommendations to reduce DM risk.

AB - The incidence of type 2 diabetes mellitus (DM) has increased in the US over the last several years. The consumption of low-fat dairy foods has been linked with decreasing the risk of DM but studies have yet to show a clear correlation. We conducted a systematic review and meta-analysis of randomized clinical trials (RCTs) evaluating the effects of dairy intake on homeostatic model assessment of insulin resistance (HOMA-IR), waist circumference, and body weight. In MEDLINE and Embase, we identified and reviewed 49 relevant RCTs: 30 had appropriate data format for inclusion in the meta-analysis. Using the Review Manager 5 software, we calculated the pooled standardized mean differences comparing dairy dietary interventions to control for our outcomes of interest. For HOMA-IR (794 individuals), we found a mean difference of -1.21 (95% CI -1.74 to -0.67; p-value < 0.00001; I2 = 92%). For waist circumference (1348 individuals), the mean difference was -1.09 cm (95% CI 1.68 to -0.58; p-value < 0.00001; I2 = 94%). For body weight (2362 individuals), the dairy intake intervention group weighed 0.42 kg less than control (p-value < 0.00001; I2 = 92%). Our findings suggest that dairy intake, especially low-fat dairy products, has a beneficial effect on HOMA-IR, waist circumference, and body weight. This could impact dietary recommendations to reduce DM risk.

KW - dairy intake

KW - diet

KW - insulin resistance

KW - low-fat dairy

KW - waist circumference

KW - weight loss

UR - http://www.scopus.com/inward/record.url?scp=85072378634&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85072378634&partnerID=8YFLogxK

U2 - 10.3390/nu11092237

DO - 10.3390/nu11092237

M3 - Article

C2 - 31533272

AN - SCOPUS:85072378634

VL - 11

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 9

ER -