The effects of 4-aminoantifolates on 5-formyltetrahydrofolate metabolism in L1210 cells. A biochemical basis of the selectivity of leucovorin rescue

Medicine & Life Sciences

• Leucovorin 95%
• Folic Acid 63%
• methotrexate polyglutamate 55%
• Trimetrexate 54%
• 5,6,7,8-tetrahydrofolic acid 48%
• Methotrexate 31%
• Formyltetrahydrofolates 30%
• 10-formyltetrahydropteroylglutamic acid 30%
• 5,10-methylenetetrahydrofolic acid 28%
• dihydrofolate 27%
• Purine Nucleotides 22%
• Folic Acid Antagonists 22%
• Carbon 15%
• Serine 15%
• Hydroxymethyl and Formyl Transferases 13%
• Polyglutamic Acid 12%
• Carbon Cycle 12%
• Amino Acids 11%
• Leukemia L1210 11%
• Deoxyuridine 10%
• Thymidylate Synthase 10%
• formic acid 10%
• Biosynthetic Pathways 9%
• Drug and Narcotic Control 9%
• purine 9%
• Methionine 8%
• Glycine 8%
• Nucleic Acids 7%
• Bone Marrow Cells 7%
• Gastrointestinal Tract 6%
• Pharmaceutical Preparations 6%
• Nucleotides 6%
• Enzymes 4%
• Growth 4%
• Neoplasms 2%

Chemical Compounds

• Methotrexate 100%
• Trimetrexate 72%
• Pharmacological Metabolism 61%
• Tetrahydrofolate 57%
• Folate 35%
• Purine Nucleotide 28%
• Formyl Group 26%
• Dihydrofolates 25%
• Serine 18%
• Antifolate 14%
• Folic Acid 11%
• Methionine 10%
• Formate 10%
• Purine 10%
• Cofactor 9%
• Glycine 8%
• Nucleic Acid 8%
• Nucleotide 8%
• Metabolite 7%
• Acid 6%
• Flow 6%
• Carbon Atom 4%