The Effect of Preoperative Vitamin K on the INR in Bridging Therapy

Ashrei Bayewitz, Barbara Scorziello, Clarice Maala, Emily Giannattasio, Henny H. Billett

Research output: Contribution to journalArticle

Abstract

We investigated a bridging protocol using oral Vitamin K three days before scheduled surgery. 60 patients in two bridging protocols, 30 cases per protocol. The first cohort (Control group) had its warfarin held on Day-5 (five days before surgery). The intervention cohort (Vitamin K group) routinely received 2.5 mg of oral Vitamin K on Day-3 but was otherwise identically bridged. Primary outcome was INR on Day-1. Secondary outcomes included patients with INRs ≥1.5 on Day-1, bleeding episodes and elevated INR post surgery. Day-1 INR for the Vitamin K group was 1.16, vs. 1.28 for the Control group (p = 0.037). Postoperative INR was similar. Only the Control group had patients with INRs ≥1.5 on Day-1, or patients with significant bleeding. Adding Vitamin K on Day-3 leads to a safe preoperative INR and may limit other complications.

Original languageEnglish (US)
Pages (from-to)264-267
Number of pages4
JournalInternational Journal of Hematology
Volume101
Issue number3
DOIs
StatePublished - 2015

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International Normalized Ratio
Vitamin K
Control Groups
Therapeutics
Hemorrhage
Vitamin K 1
Warfarin
Ambulatory Surgical Procedures

Keywords

  • Anticoagulation
  • Bridging therapy
  • Vitamin K

ASJC Scopus subject areas

  • Hematology
  • Medicine(all)

Cite this

The Effect of Preoperative Vitamin K on the INR in Bridging Therapy. / Bayewitz, Ashrei; Scorziello, Barbara; Maala, Clarice; Giannattasio, Emily; Billett, Henny H.

In: International Journal of Hematology, Vol. 101, No. 3, 2015, p. 264-267.

Research output: Contribution to journalArticle

Bayewitz, Ashrei ; Scorziello, Barbara ; Maala, Clarice ; Giannattasio, Emily ; Billett, Henny H. / The Effect of Preoperative Vitamin K on the INR in Bridging Therapy. In: International Journal of Hematology. 2015 ; Vol. 101, No. 3. pp. 264-267.
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