The effect of phototherapy on intestinal mucosal enzyme activity in the gunn rat

Gabriel Dinari; Michael I. Cohen; Helen McNamara; Fredric Daum

doi:10.1159/000241361

The effect of phototherapy on intestinal mucosal enzyme activity in the gunn rat

Gabriel Dinari, Michael I. Cohen, Helen McNamara, Fredric Daum

Pediatrics

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Infants undergoing phototherapy may develop loose stools. Acquired lactase deficiency secondary to this treatment modality was suggested as a cause for the diarrhea. The effects of light energy directly on intestinal enzymes and indirectly through bilirubin photooxidation products were studied. Adult homozygote and heterozygote Gunn rats were treated with light for varying periods while littermate controls were kept in the dark. Intestinal lactase, sucrase and GGTP activities and serum bilirubin concentrations were determined. Jaundiced and non-jaundiced 1-week-old suckling Gunn rats were treated with light for 96 h, and intestinal lactase activity determined. No decreases in lactase, sucrase or GGTP activities were observed suggesting the reported diarrheal states following phototherapy are not related to light energy or photooxidation products.

Original language	English (US)
Pages (from-to)	179-184
Number of pages	6
Journal	Neonatology
Volume	38
Issue number	3-4
DOIs	https://doi.org/10.1159/000241361
State	Published - 1980

Keywords

Bilirubin
Diarrhea
GGTP
Gunn rat
Lactase
Phototherapy
Sucrase

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Developmental Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000241361

Cite this

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abstract = "Infants undergoing phototherapy may develop loose stools. Acquired lactase deficiency secondary to this treatment modality was suggested as a cause for the diarrhea. The effects of light energy directly on intestinal enzymes and indirectly through bilirubin photooxidation products were studied. Adult homozygote and heterozygote Gunn rats were treated with light for varying periods while littermate controls were kept in the dark. Intestinal lactase, sucrase and GGTP activities and serum bilirubin concentrations were determined. Jaundiced and non-jaundiced 1-week-old suckling Gunn rats were treated with light for 96 h, and intestinal lactase activity determined. No decreases in lactase, sucrase or GGTP activities were observed suggesting the reported diarrheal states following phototherapy are not related to light energy or photooxidation products.",

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AU - Dinari, Gabriel

AU - Cohen, Michael I.

AU - McNamara, Helen

AU - Daum, Fredric

PY - 1980

Y1 - 1980

N2 - Infants undergoing phototherapy may develop loose stools. Acquired lactase deficiency secondary to this treatment modality was suggested as a cause for the diarrhea. The effects of light energy directly on intestinal enzymes and indirectly through bilirubin photooxidation products were studied. Adult homozygote and heterozygote Gunn rats were treated with light for varying periods while littermate controls were kept in the dark. Intestinal lactase, sucrase and GGTP activities and serum bilirubin concentrations were determined. Jaundiced and non-jaundiced 1-week-old suckling Gunn rats were treated with light for 96 h, and intestinal lactase activity determined. No decreases in lactase, sucrase or GGTP activities were observed suggesting the reported diarrheal states following phototherapy are not related to light energy or photooxidation products.

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KW - Lactase

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KW - Sucrase

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The effect of phototherapy on intestinal mucosal enzyme activity in the gunn rat

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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