The effect of phosphoramidon on inflammation-mediated preterm delivery in a mouse model

Karen L. Koscica, Georges Sylvestre, Sandra E. Reznik

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Objective: Several metallopeptidases have been implicated in both term and preterm parturition. We hypothesize that endotoxin-induced preterm delivery can be prevented by the administration of a metallopeptidase inhibitor. Study design: We used an animal model of endotoxin-induced preterm delivery in timed pregnancy C57B1/6 mice. Test animals received lipopolysaccharide followed by phosphoramidon, either every 1.5 or every 3 hours. Control mice received lipopolysaccharide followed by buffer injections at the same intervals. The primary outcome was a preterm delivery rate. Results: The rate of preterm delivery for the control animals was 88.0% compared with the treatment groups of 45.5% for the mice that received phosphoramidon every 3 hours and 30.8% for the group that received it every 1.5 hours (P < .01). Conclusion: The administration of a metallopeptidase inhibitor resulted in a decreased rate of preterm delivery in this animal model.

Original languageEnglish (US)
Pages (from-to)528-531
Number of pages4
JournalAmerican Journal of Obstetrics and Gynecology
Volume190
Issue number2
DOIs
Publication statusPublished - Feb 2004

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Keywords

  • Cytokine
  • Metallopeptidase
  • Phosphoramidon
  • Preterm delivery

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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