The effect of maternal heroin addiction on neonatal jaundice

Gerald Nathenson, Michael I. Cohen, Iris F. Litt, Helen McNamara

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The lack of significant jaundice among infants of heroin-addicted mothers suggested a possible mitigating effect of heroin on bilirubin accumulation in the newborn infant. This possibility was substantiated by the finding of increased bilirubin glucuronyl transferase activity in morphine-addicted mice and the morphologic demonstration of an increase in the smooth endoplasmic reticulum of their liver cells as seen by electron microscopy. The significance of enhanced glucuronyl transferase activity may extend beyond the metabolism of bilirubin.

Original languageEnglish (US)
Pages (from-to)899-903
Number of pages5
JournalThe Journal of Pediatrics
Volume81
Issue number5
DOIs
StatePublished - 1972

Fingerprint

Neonatal Jaundice
Heroin Dependence
bilirubin glucuronoside glucuronosyltransferase
Heroin
Bilirubin
Mothers
Smooth Endoplasmic Reticulum
Transferases
Jaundice
Morphine
Electron Microscopy
Newborn Infant
Liver

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

The effect of maternal heroin addiction on neonatal jaundice. / Nathenson, Gerald; Cohen, Michael I.; Litt, Iris F.; McNamara, Helen.

In: The Journal of Pediatrics, Vol. 81, No. 5, 1972, p. 899-903.

Research output: Contribution to journalArticle

Nathenson, Gerald ; Cohen, Michael I. ; Litt, Iris F. ; McNamara, Helen. / The effect of maternal heroin addiction on neonatal jaundice. In: The Journal of Pediatrics. 1972 ; Vol. 81, No. 5. pp. 899-903.
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