The effect of maternal heroin addiction on neonatal jaundice

Gerald Nathenson; Michael I. Cohen; Iris F. Litt; Helen McNamara

doi:10.1016/S0022-3476(72)80540-7

The effect of maternal heroin addiction on neonatal jaundice

Gerald Nathenson, Michael I. Cohen, Iris F. Litt, Helen McNamara

Pediatrics

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

The lack of significant jaundice among infants of heroin-addicted mothers suggested a possible mitigating effect of heroin on bilirubin accumulation in the newborn infant. This possibility was substantiated by the finding of increased bilirubin glucuronyl transferase activity in morphine-addicted mice and the morphologic demonstration of an increase in the smooth endoplasmic reticulum of their liver cells as seen by electron microscopy. The significance of enhanced glucuronyl transferase activity may extend beyond the metabolism of bilirubin.

Original language	English (US)
Pages (from-to)	899-903
Number of pages	5
Journal	The Journal of Pediatrics
Volume	81
Issue number	5
DOIs	https://doi.org/10.1016/S0022-3476(72)80540-7
State	Published - Nov 1972

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.1016/S0022-3476(72)80540-7

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title = "The effect of maternal heroin addiction on neonatal jaundice",

abstract = "The lack of significant jaundice among infants of heroin-addicted mothers suggested a possible mitigating effect of heroin on bilirubin accumulation in the newborn infant. This possibility was substantiated by the finding of increased bilirubin glucuronyl transferase activity in morphine-addicted mice and the morphologic demonstration of an increase in the smooth endoplasmic reticulum of their liver cells as seen by electron microscopy. The significance of enhanced glucuronyl transferase activity may extend beyond the metabolism of bilirubin.",

author = "Gerald Nathenson and Cohen, {Michael I.} and Litt, {Iris F.} and Helen McNamara",

note = "Funding Information: Supported by United States Public Health Service Grant AM 13785.",

year = "1972",

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doi = "10.1016/S0022-3476(72)80540-7",

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T1 - The effect of maternal heroin addiction on neonatal jaundice

AU - Nathenson, Gerald

AU - Cohen, Michael I.

AU - Litt, Iris F.

AU - McNamara, Helen

N1 - Funding Information: Supported by United States Public Health Service Grant AM 13785.

PY - 1972/11

Y1 - 1972/11

N2 - The lack of significant jaundice among infants of heroin-addicted mothers suggested a possible mitigating effect of heroin on bilirubin accumulation in the newborn infant. This possibility was substantiated by the finding of increased bilirubin glucuronyl transferase activity in morphine-addicted mice and the morphologic demonstration of an increase in the smooth endoplasmic reticulum of their liver cells as seen by electron microscopy. The significance of enhanced glucuronyl transferase activity may extend beyond the metabolism of bilirubin.

AB - The lack of significant jaundice among infants of heroin-addicted mothers suggested a possible mitigating effect of heroin on bilirubin accumulation in the newborn infant. This possibility was substantiated by the finding of increased bilirubin glucuronyl transferase activity in morphine-addicted mice and the morphologic demonstration of an increase in the smooth endoplasmic reticulum of their liver cells as seen by electron microscopy. The significance of enhanced glucuronyl transferase activity may extend beyond the metabolism of bilirubin.

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The effect of maternal heroin addiction on neonatal jaundice

Abstract

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