The effect of fibroids without cavity involvement on ART outcomes independent of ovarian age

P. C. Klatsky, D. E. Lane, I. P. Ryan, V. Y. Fujimoto

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Background: The effect of fibroids that do not distort the endometrial cavity on pregnancy rate (PR) and implantation rate (IR) is controversial. Use of oocyte donor-derived embryos offers an ideal patient population to study the effect of fibroids in patients utilizing assisted reproductive technologies (ARTs). Methods: We conducted a retrospective cohort study of patients undergoing oocyte donor recipient (ODR) IVF cycles at two tertiary care fertility centres. We examined medical records for the presence of non-cavity-distorting fibroids and evaluated subsequent PR and IR. Results: Three hundred and sixty-nine patients, 94 with fibroids, underwent oocyte donor recipient transfer cycles with fresh embryos. There was no statistical difference in IR (36 versus 38%) or clinical PR (47 versus 54%) between patients with or without fibroids. Neither the location (subserosal versus intramural) and the presence of multiple myomas nor the size of the myomas affected outcomes. Fibroids were more likely to be present in patients with increasing recipient age. Conclusions: Clinical PR and IR are not affected by the presence of non-cavity-distorting leiomyomata. This evidence does not support myomectomy before ART in patients with asymptomatic fibroids that do not significantly distort the endometrial cavity or cause abnormal uterine bleeding.

Original languageEnglish (US)
Pages (from-to)521-526
Number of pages6
JournalHuman Reproduction
Volume22
Issue number2
DOIs
StatePublished - Feb 2007
Externally publishedYes

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Assisted Reproductive Techniques
Leiomyoma
Pregnancy Rate
Oocytes
Myoma
Tissue Donors
Uterine Myomectomy
Embryonic Structures
Uterine Hemorrhage
Tertiary Care Centers
Medical Records
Fertility
Cohort Studies
Retrospective Studies

Keywords

  • ART
  • Fibroid
  • Myoma
  • Oocyte donor

ASJC Scopus subject areas

  • Physiology
  • Developmental Biology
  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

The effect of fibroids without cavity involvement on ART outcomes independent of ovarian age. / Klatsky, P. C.; Lane, D. E.; Ryan, I. P.; Fujimoto, V. Y.

In: Human Reproduction, Vol. 22, No. 2, 02.2007, p. 521-526.

Research output: Contribution to journalArticle

Klatsky, P. C. ; Lane, D. E. ; Ryan, I. P. ; Fujimoto, V. Y. / The effect of fibroids without cavity involvement on ART outcomes independent of ovarian age. In: Human Reproduction. 2007 ; Vol. 22, No. 2. pp. 521-526.
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