The effect of dietary omega-3 polyunsaturated fatty acids on plasma lipids and lipoproteins of C57BL/6 mice is age and sex specific

K. A. Balogun, R. S. Randunu, S. K. Cheema

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

There is clear evidence of the effects of sex and age on the prevalence of cardiovascular disease. We investigated the interactions of dietary omega ( n)-3 polyunsaturated fatty acids (PUFA), sex, and age on plasma lipids and lipoproteins in the offspring of C57BL/6 mice exposed to high, medium, or low n-3 PUFA at weaning and 16 weeks postweaning. There was an increase in plasma triglycerides from weaning to 16 weeks in male and female offspring however, the high n-3 PUFA group showed a reduction in triglycerides in both sexes at 16 weeks. High n-3 PUFA caused an increase in plasma LDL-cholesterol from weaning to 16 weeks in male offspring however, the LDL particle size was significantly larger in the high n-3 PUFA group. Plasma from male mice showed higher cholesterol efflux compared to females; high n-3 PUFA increased cholesterol efflux. Thus the effects of n-3 PUFA are age and sex dependent.

Original languageEnglish (US)
Pages (from-to)39-47
Number of pages9
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Volume91
Issue number1-2
DOIs
StatePublished - Jul 2014
Externally publishedYes

Keywords

  • Age
  • Cholesterol efflux
  • Lipids and lipoproteins
  • N-3 PUFA
  • Sex

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology

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