The effect of colchicine on guinea pig intestinal enzyme activity

Michael I. Cohen, Helen McNamara

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The intestinal mucosal reaction to colchicine in guinea pigs as measured by sucrase, maltase, and gamma glutamyl transpeptidase activity is described. There is a significant fall in disaccharidase activity without alteration in the peptidase activity after colchicine administration. This suggests a specific response of the disaccharidase system rather than a generalized toxic mucosal effect of colchicine.

Original languageEnglish (US)
Pages (from-to)247-250
Number of pages4
JournalThe American Journal of Digestive Diseases
Volume15
Issue number3
DOIs
StatePublished - Mar 1970

Fingerprint

Colchicine
Disaccharidases
Guinea Pigs
Enzymes
Sucrase
alpha-Glucosidases
gamma-Glutamyltransferase
Poisons
Peptide Hydrolases

ASJC Scopus subject areas

  • Gastroenterology
  • Medicine(all)

Cite this

The effect of colchicine on guinea pig intestinal enzyme activity. / Cohen, Michael I.; McNamara, Helen.

In: The American Journal of Digestive Diseases, Vol. 15, No. 3, 03.1970, p. 247-250.

Research output: Contribution to journalArticle

@article{cd6322f040384268ab6f1f103ce505a2,
title = "The effect of colchicine on guinea pig intestinal enzyme activity",
abstract = "The intestinal mucosal reaction to colchicine in guinea pigs as measured by sucrase, maltase, and gamma glutamyl transpeptidase activity is described. There is a significant fall in disaccharidase activity without alteration in the peptidase activity after colchicine administration. This suggests a specific response of the disaccharidase system rather than a generalized toxic mucosal effect of colchicine.",
author = "Cohen, {Michael I.} and Helen McNamara",
year = "1970",
month = "3",
doi = "10.1007/BF02233455",
language = "English (US)",
volume = "15",
pages = "247--250",
journal = "Digestive Diseases and Sciences",
issn = "0163-2116",
publisher = "Plenum Publishers",
number = "3",

}

TY - JOUR

T1 - The effect of colchicine on guinea pig intestinal enzyme activity

AU - Cohen, Michael I.

AU - McNamara, Helen

PY - 1970/3

Y1 - 1970/3

N2 - The intestinal mucosal reaction to colchicine in guinea pigs as measured by sucrase, maltase, and gamma glutamyl transpeptidase activity is described. There is a significant fall in disaccharidase activity without alteration in the peptidase activity after colchicine administration. This suggests a specific response of the disaccharidase system rather than a generalized toxic mucosal effect of colchicine.

AB - The intestinal mucosal reaction to colchicine in guinea pigs as measured by sucrase, maltase, and gamma glutamyl transpeptidase activity is described. There is a significant fall in disaccharidase activity without alteration in the peptidase activity after colchicine administration. This suggests a specific response of the disaccharidase system rather than a generalized toxic mucosal effect of colchicine.

UR - http://www.scopus.com/inward/record.url?scp=0014747661&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0014747661&partnerID=8YFLogxK

U2 - 10.1007/BF02233455

DO - 10.1007/BF02233455

M3 - Article

VL - 15

SP - 247

EP - 250

JO - Digestive Diseases and Sciences

JF - Digestive Diseases and Sciences

SN - 0163-2116

IS - 3

ER -