The Effect of Antineoplastic Drugs in a Male Spontaneous Mammary Tumor Model

Stephanie N. Shishido, Emma B. Faulkner, Amanda P. Beck, Thu A. Nguyen

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Male breast cancer is a rare disease. The limited number of clinical cases has led to the primary treatments for men being derived from female breast cancer studies. Here the transgenic strain FVB/N-Tg(MMTV-PyVT)634Mul/J (also known as PyVT) was used as a model system for measuring tumor burden and drug sensitivity of the antineoplastic drugs tamoxifen, cisplatin, and paclitaxel on tumorigenesis at an early stage of mammary carcinoma development in a male mouse model. Cisplatin treatment significantly reduced tumor volume, while paclitaxel and tamoxifen did not attenuate tumor growth. Cisplatin treatment was shown to induce apoptosis, grossly observed by reduced tumor formation, through reduced Bcl-2 and survivin protein expression levels with an increase in caspase 3 expression compared to control tumors. Tamoxifen treatment significantly altered the hormone receptor expression levels of the tumor, while additionally upregulating Bcl-2 and Cyclin D1. This suggests an importance in hormonal signaling in male breast cancer pathogenesis. The results of this study provide valuable information toward the better understanding of male breast cancer and may help guide treatment decisions.

Original languageEnglish (US)
Article numbere64866
JournalPLoS One
Volume8
Issue number6
DOIs
StatePublished - Jun 3 2013
Externally publishedYes

Fingerprint

Male Breast Neoplasms
mammary neoplasms (animal)
Antineoplastic Agents
Tumors
breast neoplasms
tamoxifen
drugs
Tamoxifen
cisplatin
neoplasms
Cisplatin
Tumor Burden
paclitaxel
Paclitaxel
Neoplasms
Breast Neoplasms
Therapeutics
Cyclin D1
Rare Diseases
Caspase 3

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

The Effect of Antineoplastic Drugs in a Male Spontaneous Mammary Tumor Model. / Shishido, Stephanie N.; Faulkner, Emma B.; Beck, Amanda P.; Nguyen, Thu A.

In: PLoS One, Vol. 8, No. 6, e64866, 03.06.2013.

Research output: Contribution to journalArticle

Shishido, Stephanie N. ; Faulkner, Emma B. ; Beck, Amanda P. ; Nguyen, Thu A. / The Effect of Antineoplastic Drugs in a Male Spontaneous Mammary Tumor Model. In: PLoS One. 2013 ; Vol. 8, No. 6.
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