Abstract
Trypanosoma cruzi (Brazil strain) was maintained in liver infusion tryptose medium supplemented with 5 or 10% foetal calf serum at 27 °C on a rotating shaker platform. 85 to 95% of the organisms under these conditions are epimastigotes and the medium supported logarithmic growth for up to 24 hours. The effect of S-isobutyl adenosine and SinefunginR against cultured T. cruzi epimastigotes was studied: growth rate was slowed by both in a dose-dependent fashion; 500 μm Sinefungin caused complete inhibition which was irreversible after 24-hour exposure but the effect of S-isobutyl adenosine (1000 μm) was reversible. Motility and morphology appeared to be unaffected.
Original language | English (US) |
---|---|
Pages (from-to) | 285-287 |
Number of pages | 3 |
Journal | Transactions of the Royal Society of Tropical Medicine and Hygiene |
Volume | 76 |
Issue number | 3 |
DOIs | |
State | Published - 1982 |
ASJC Scopus subject areas
- Parasitology
- Public Health, Environmental and Occupational Health
- Infectious Diseases