The effect of adenosine analogues on the in vitro growth of trypanosoma cruzi

Jeffrey P. Nadler, Edgar Lederer, Murray Wittner, Stephen G. Baum, Herbert B. Tanowitz

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Trypanosoma cruzi (Brazil strain) was maintained in liver infusion tryptose medium supplemented with 5 or 10% foetal calf serum at 27 °C on a rotating shaker platform. 85 to 95% of the organisms under these conditions are epimastigotes and the medium supported logarithmic growth for up to 24 hours. The effect of S-isobutyl adenosine and SinefunginR against cultured T. cruzi epimastigotes was studied: growth rate was slowed by both in a dose-dependent fashion; 500 μm Sinefungin caused complete inhibition which was irreversible after 24-hour exposure but the effect of S-isobutyl adenosine (1000 μm) was reversible. Motility and morphology appeared to be unaffected.

Original languageEnglish (US)
Pages (from-to)285-287
Number of pages3
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
Volume76
Issue number3
DOIs
StatePublished - 1982

ASJC Scopus subject areas

  • Parasitology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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