The effect of a nitric oxide inhibitor (L-name) on peritoneal transport during dialysis in rats

Andrzej Breborowicz, Katarzyna Wieczorowska-Tobis, Katarzyna Korybalska, Alicja Polubinska, Maciej Radkowski, Dimitrios G. Oreopoulos

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Objective: To assess the effect of an inhibitor of nitric oxide synthesis [N(G)-nitro-L-arginine methyl ester (L-NAME)] on peritoneal transport during peritoneal dialysis (PD) and peritonitis in rats. Methods: The authors studied peritoneal transport of small and large solutes, and net ultrafiltration (UF) in rats during PD with Dianeal 3.86 (Baxter, McGaw Park, IL, U.S.A.). They evaluated the effect of L-NAME used as an additive to dialysis fluid in concentrations 0.5-5 mg/mL on peritoneal transport of small and large molecules and on transperitoneal UF. In addition, they studied the effect of L-NAME (5 mg/ml) during acute peritonitis induced by lipopolysaccharides (5 μg/mL) given intraperitoneally. Results: The addition of L-NAME to dialysis fluid increased the selectivity of the peritoneum and net UF during dialysis. Lipopolysaccharides used as an additive to the dialysis fluid, together with L-NAME, did not induce changes in transperitoneal transport of small and large solutes and did not cause a significant decline in net UF. L-NAME given intraperitoneally reduced both local and systemic production of nitric oxide, which might explain its effects on peritoneal transport. Conclusions: Nitric oxide is an important mediator of changes in peritoneal transport and its effect is especially significant during peritonitis.

Original languageEnglish (US)
Pages (from-to)188-192
Number of pages5
JournalPeritoneal Dialysis International
Volume18
Issue number2
StatePublished - Mar 1998
Externally publishedYes

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NG-Nitroarginine Methyl Ester
Names
Dialysis
Nitric Oxide
Ultrafiltration
Peritonitis
Peritoneal Dialysis
Lipopolysaccharides
Peritoneum

Keywords

  • Nitric oxide
  • Peritoneal transport
  • Peritonitis

ASJC Scopus subject areas

  • Nephrology

Cite this

Breborowicz, A., Wieczorowska-Tobis, K., Korybalska, K., Polubinska, A., Radkowski, M., & Oreopoulos, D. G. (1998). The effect of a nitric oxide inhibitor (L-name) on peritoneal transport during dialysis in rats. Peritoneal Dialysis International, 18(2), 188-192.

The effect of a nitric oxide inhibitor (L-name) on peritoneal transport during dialysis in rats. / Breborowicz, Andrzej; Wieczorowska-Tobis, Katarzyna; Korybalska, Katarzyna; Polubinska, Alicja; Radkowski, Maciej; Oreopoulos, Dimitrios G.

In: Peritoneal Dialysis International, Vol. 18, No. 2, 03.1998, p. 188-192.

Research output: Contribution to journalArticle

Breborowicz, A, Wieczorowska-Tobis, K, Korybalska, K, Polubinska, A, Radkowski, M & Oreopoulos, DG 1998, 'The effect of a nitric oxide inhibitor (L-name) on peritoneal transport during dialysis in rats', Peritoneal Dialysis International, vol. 18, no. 2, pp. 188-192.
Breborowicz A, Wieczorowska-Tobis K, Korybalska K, Polubinska A, Radkowski M, Oreopoulos DG. The effect of a nitric oxide inhibitor (L-name) on peritoneal transport during dialysis in rats. Peritoneal Dialysis International. 1998 Mar;18(2):188-192.
Breborowicz, Andrzej ; Wieczorowska-Tobis, Katarzyna ; Korybalska, Katarzyna ; Polubinska, Alicja ; Radkowski, Maciej ; Oreopoulos, Dimitrios G. / The effect of a nitric oxide inhibitor (L-name) on peritoneal transport during dialysis in rats. In: Peritoneal Dialysis International. 1998 ; Vol. 18, No. 2. pp. 188-192.
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