The early folding intermediates of the tetrahymena ribozyme are kinetically trapped

Corie Y. Ralston, Bianca Sclavi, Michael Brenowitz, Michael Sullivan, Mark R. Chance

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The "RNA folding problem" is a fundamental and challenging question in contemporary biophysics. Understanding the mechanism(s) by which RNA molecules fold into compact structures capable of biological activity is important because RNA folding is closely tied to cellular regulation and metabolism and catalytic RNAs are potential reagents for gene therapy. Unlike the "protein folding problem" which has been under study for many decades, the study of RNA tertiary structure stability and folding is a relatively new field of endeavor. Thus, a detailed understanding of both the thermodynamics and kinetics of RNA folding are only now beginning to emerge.

Original languageEnglish (US)
Pages (from-to)195-200
Number of pages6
JournalJournal of Biomolecular Structure and Dynamics
Volume17
Issue numberSUPPL. 1
DOIs
StatePublished - Dec 1 2000

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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