The duration of leuprolide acetate administration prior to ovulation induction does not impact ovarian responsiveness to exogenous gonadotropins

R. T. Scott, G. S. Neal, E. H. Illions, C. A. Hayslip, G. E. Hofmann

Research output: Contribution to journalArticle

12 Scopus citations


Objective: To evaluate the possible impact that the duration of GnRH agonist (GnRH-a) suppression has on subsequent ovarian responsiveness to exogenous gonadotropins. Design: Prospective evaluation of the relationship between the duration of GnRH-a and multiple parameters of ovarian responsiveness. Setting: Assisted reproduction program in a large military tertiary care center. Patients: One hundred sixty-five women being pretreated with leuprolide acetate (LA) before ovulation induction with exogenous gonadotropins. Interventions: Variable duration of LA administration before stimulation. Main Outcome Measures: Outcome measures include duration of stimulation, days until doubling of basal E2, number of ampules of exogenous gonadotropins, peak E2, number of mature follicles, and number of mature oocytes. Results: The duration of LA pretreatment had no effect on any of the parameters of ovarian responsiveness analyzed. Conclusion: Once complete suppression of gonadal function is attained, the duration of GnRH-a suppression has no impact on subsequent ovarian responsiveness to exogenous gonadotropins.

Original languageEnglish (US)
Pages (from-to)247-253
Number of pages7
JournalFertility and Sterility
Issue number2
Publication statusPublished - Jan 1 1993



  • GnRH agonists
  • Gonadorelin
  • leuprolide acetate
  • ovulation induction

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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