The discovery of Bombali virus adds further support for bats as hosts of ebolaviruses

Tracey Goldstein; Simon J. Anthony; Aiah Gbakima; Brian H. Bird; James Bangura; Alexandre Tremeau-Bravard; Manjunatha N. Belaganahalli; Heather L. Wells; Jasjeet K. Dhanota; Eliza Liang; Michael Grodus; Rohit K. Jangra; Veronica A. DeJesus; Gorka Lasso; Brett R. Smith; Amara Jambai; Brima O. Kamara; Sorie Kamara; William Bangura; Corina Monagin; Sagi Shapira; Christine K. Johnson; Karen Saylors; Edward M. Rubin; Kartik Chandran; W. Ian Lipkin; Jonna A.K. Mazet

doi:10.1038/s41564-018-0227-2

The discovery of Bombali virus adds further support for bats as hosts of ebolaviruses

Tracey Goldstein, Simon J. Anthony, Aiah Gbakima, Brian H. Bird, James Bangura, Alexandre Tremeau-Bravard, Manjunatha N. Belaganahalli, Heather L. Wells, Jasjeet K. Dhanota, Eliza Liang, Michael Grodus, Rohit K. Jangra, Veronica A. DeJesus, Gorka Lasso, Brett R. Smith, Amara Jambai, Brima O. Kamara, Sorie Kamara, William Bangura, Corina MonaginSagi Shapira, Christine K. Johnson, Karen Saylors, Edward M. Rubin, Kartik Chandran, W. Ian Lipkin, Jonna A.K. Mazet

Microbiology & Immunology

Research output: Contribution to journal › Article › peer-review

244 Scopus citations

Abstract

Here we describe the complete genome of a new ebolavirus, Bombali virus (BOMV) detected in free-tailed bats in Sierra Leone (little free-tailed (Chaerephon pumilus) and Angolan free-tailed (Mops condylurus)). The bats were found roosting inside houses, indicating the potential for human transmission. We show that the viral glycoprotein can mediate entry into human cells. However, further studies are required to investigate whether exposure has actually occurred or if BOMV is pathogenic in humans.

Original language	English (US)
Pages (from-to)	1084-1089
Number of pages	6
Journal	Nature Microbiology
Volume	3
Issue number	10
DOIs	https://doi.org/10.1038/s41564-018-0227-2
State	Published - Oct 1 2018

ASJC Scopus subject areas

Microbiology
Immunology
Applied Microbiology and Biotechnology
Genetics
Microbiology (medical)
Cell Biology

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Goldstein, T., Anthony, S. J., Gbakima, A., Bird, B. H., Bangura, J., Tremeau-Bravard, A., Belaganahalli, M. N., Wells, H. L., Dhanota, J. K., Liang, E., Grodus, M., Jangra, R. K., DeJesus, V. A., Lasso, G., Smith, B. R., Jambai, A., Kamara, B. O., Kamara, S., Bangura, W., ... Mazet, J. A. K. (2018). The discovery of Bombali virus adds further support for bats as hosts of ebolaviruses. Nature Microbiology, 3(10), 1084-1089. https://doi.org/10.1038/s41564-018-0227-2

Goldstein, T, Anthony, SJ, Gbakima, A, Bird, BH, Bangura, J, Tremeau-Bravard, A, Belaganahalli, MN, Wells, HL, Dhanota, JK, Liang, E, Grodus, M, Jangra, RK, DeJesus, VA, Lasso, G, Smith, BR, Jambai, A, Kamara, BO, Kamara, S, Bangura, W, Monagin, C, Shapira, S, Johnson, CK, Saylors, K, Rubin, EM, Chandran, K, Lipkin, WI & Mazet, JAK 2018, 'The discovery of Bombali virus adds further support for bats as hosts of ebolaviruses', Nature Microbiology, vol. 3, no. 10, pp. 1084-1089. https://doi.org/10.1038/s41564-018-0227-2

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abstract = "Here we describe the complete genome of a new ebolavirus, Bombali virus (BOMV) detected in free-tailed bats in Sierra Leone (little free-tailed (Chaerephon pumilus) and Angolan free-tailed (Mops condylurus)). The bats were found roosting inside houses, indicating the potential for human transmission. We show that the viral glycoprotein can mediate entry into human cells. However, further studies are required to investigate whether exposure has actually occurred or if BOMV is pathogenic in humans.",

author = "Tracey Goldstein and Anthony, {Simon J.} and Aiah Gbakima and Bird, {Brian H.} and James Bangura and Alexandre Tremeau-Bravard and Belaganahalli, {Manjunatha N.} and Wells, {Heather L.} and Dhanota, {Jasjeet K.} and Eliza Liang and Michael Grodus and Jangra, {Rohit K.} and DeJesus, {Veronica A.} and Gorka Lasso and Smith, {Brett R.} and Amara Jambai and Kamara, {Brima O.} and Sorie Kamara and William Bangura and Corina Monagin and Sagi Shapira and Johnson, {Christine K.} and Karen Saylors and Rubin, {Edward M.} and Kartik Chandran and Lipkin, {W. Ian} and Mazet, {Jonna A.K.}",

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AU - Tremeau-Bravard, Alexandre

AU - Belaganahalli, Manjunatha N.

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AU - Jangra, Rohit K.

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AU - Kamara, Brima O.

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AU - Bangura, William

AU - Monagin, Corina

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AU - Johnson, Christine K.

AU - Saylors, Karen

AU - Rubin, Edward M.

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The discovery of Bombali virus adds further support for bats as hosts of ebolaviruses

Abstract

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