TY - JOUR
T1 - The Dimensional Yale-Brown Obsessive-Compulsive Scale (DY-BOCS)
T2 - An instrument for assessing obsessive-compulsive symptom dimensions
AU - Rosario-Campos, M. C.
AU - Miguel, E. C.
AU - Quatrano, S.
AU - Chacon, P.
AU - Ferrao, Y.
AU - Findley, D.
AU - Katsovich, L.
AU - Scahill, L.
AU - King, R. A.
AU - Woody, S. R.
AU - Tolin, D.
AU - Hollander, E.
AU - Kano, Y.
AU - Leckman, J. F.
N1 - Funding Information:
This research was funded by NIH grants MH493515, MH61940, RR00044, and RR00125; Fundac¸ão de Amparo à Pesquisa do Estado de São Paulo grant 03/07451-6 (MCR-C) and 99/12205-7 (ECM); grants from the Tourette Syndrome Association (MCR-C), the Obsessive–Compulsive Foundation (MCR-C), the Echlin Foundation and the Kaiser Family. The authors thank David Mataix-Cols, PhD, Steven A Rasmussen, MD, David L. Pauls, PhD, and Scott L Rauch, MD for their help in the development of this instrument.
PY - 2006/5
Y1 - 2006/5
N2 - Obsessive-compulsive disorder (OCD) encompasses a broad range of symptoms representing multiple domains. This complex phenotype can be summarized using a few consistent and temporally stable symptom dimensions. The objective of this study was to assess the psychometric properties of the Dimensional Yale-Brown Obsessive-Compulsive Scale (DY-BOCS). This scale measures the presence and severity of obsessive-compulsive (OC) symptoms within six distinct dimensions that combine thematically related obsessions and compulsions. The DY-BOCS includes portions to be used as a self-report instrument and portions to be used by expert raters, including global ratings of OC symptom severity and overall impairment. We assessed 137 patients with a Diagnostic and Statistical Manual-IV diagnosis of OCD, aged 6-69 years, from sites in the USA, Canada and Brazil. Estimates of the reliability and validity of both the expert and self-report versions of the DY-BOCS were calculated and stratified according to age (pediatric vs. adult subjects). The internal consistency of each of the six symptom dimensions and the global severity score were excellent. The inter-rater agreement was also excellent for all component scores. Self-report and expert ratings were highly intercorrelated. The global DY-BOCS score was highly correlated with the total Yale-Brown Obsessive-Compulsive Scale score (Pearson r = 0.82, P < 0.0001). Severity scores for individual symptom dimensions were largely independent of one another, only modestly correlated with the global ratings, and were also differentially related to ratings of depression, anxiety and tic severity. No major differences were observed when the results were stratified by age. These results indicate that the DY-BOCS is a reliable and valid instrument for assessing multiple aspects of OCD symptom severity in natural history, neuroimaging, treatment response and genetic studies when administered by expert clinicians or their highly trained staff.
AB - Obsessive-compulsive disorder (OCD) encompasses a broad range of symptoms representing multiple domains. This complex phenotype can be summarized using a few consistent and temporally stable symptom dimensions. The objective of this study was to assess the psychometric properties of the Dimensional Yale-Brown Obsessive-Compulsive Scale (DY-BOCS). This scale measures the presence and severity of obsessive-compulsive (OC) symptoms within six distinct dimensions that combine thematically related obsessions and compulsions. The DY-BOCS includes portions to be used as a self-report instrument and portions to be used by expert raters, including global ratings of OC symptom severity and overall impairment. We assessed 137 patients with a Diagnostic and Statistical Manual-IV diagnosis of OCD, aged 6-69 years, from sites in the USA, Canada and Brazil. Estimates of the reliability and validity of both the expert and self-report versions of the DY-BOCS were calculated and stratified according to age (pediatric vs. adult subjects). The internal consistency of each of the six symptom dimensions and the global severity score were excellent. The inter-rater agreement was also excellent for all component scores. Self-report and expert ratings were highly intercorrelated. The global DY-BOCS score was highly correlated with the total Yale-Brown Obsessive-Compulsive Scale score (Pearson r = 0.82, P < 0.0001). Severity scores for individual symptom dimensions were largely independent of one another, only modestly correlated with the global ratings, and were also differentially related to ratings of depression, anxiety and tic severity. No major differences were observed when the results were stratified by age. These results indicate that the DY-BOCS is a reliable and valid instrument for assessing multiple aspects of OCD symptom severity in natural history, neuroimaging, treatment response and genetic studies when administered by expert clinicians or their highly trained staff.
KW - Obsessive-compulsive disorder
KW - Obsessive-compulsive symptom dimensions
KW - Phenotypic heterogeneity
KW - Scale
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U2 - 10.1038/sj.mp.4001798
DO - 10.1038/sj.mp.4001798
M3 - Article
C2 - 16432526
AN - SCOPUS:33646146234
SN - 1359-4184
VL - 11
SP - 495
EP - 504
JO - Molecular Psychiatry
JF - Molecular Psychiatry
IS - 5
ER -