TY - JOUR
T1 - The Development of the Bengamides as New Antibiotics against Drug-Resistant Bacteria
AU - Porras-Alcalá, Cristina
AU - Moya-Utrera, Federico
AU - García-Castro, Miguel
AU - Sánchez-Ruiz, Antonio
AU - López-Romero, Juan Manuel
AU - Pino-González, María Soledad
AU - Díaz-Morilla, Amelia
AU - Kitamura, Seiya
AU - Wolan, Dennis W.
AU - Prados, José
AU - Melguizo, Consolación
AU - Cheng-Sánchez, Iván
AU - Sarabia, Francisco
N1 - Funding Information:
Funding: Supported by grants RTI2018-098296-BI00 (Ministerio de Ciencia e Innovación), PI19/01478 from Instituto de Salud Carlos III (ISCIII) (FEDER), P20_00540 (Andalusian Government and FEDER), K99GM138758 and R35GM136286 (National Institute of General Medical Sciences of the National Institutes of Health), A-CTS-666-UGR20 (University of Granada) (FEDER), CTS-107 (Andalusian Government) and 2021-GRIN-30998 (University of Castilla-La Mancha).
Funding Information:
Acknowledgments: C.P.-A. thanks to the Ministerio de Educación, Cultura y Deporte for a predoctoral fellowship (FPI programme). F.M.-U. and M.G.-C. thank to the University of Málaga for research contracts corresponding to the research programme of the university (Plan Propio).
Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/6
Y1 - 2022/6
N2 - The bengamides comprise an interesting family of natural products isolated from sponges belonging to the prolific Jaspidae family. Their outstanding antitumor properties, coupled with their unique mechanism of action and unprecedented molecular structures, have prompted an intense research activity directed towards their total syntheses, analogue design, and biological evaluations for their development as new anticancer agents. Together with these biological studies in cancer research, in recent years, the bengamides have been identified as potential antibiotics by their impressive biological activities against various drug-resistant bacteria such as Mycobacterium tuberculosis and Staphylococcus aureus. This review reports on the new advances in the chemistry and biology of the bengamides during the last years, paying special attention to their development as promising new antibiotics. Thus, the evolution of the bengamides from their initial exploration as antitumor agents up to their current status as antibiotics is described in detail, highlighting the manifold value of these marine natural products as valid hits in medicinal chemistry.
AB - The bengamides comprise an interesting family of natural products isolated from sponges belonging to the prolific Jaspidae family. Their outstanding antitumor properties, coupled with their unique mechanism of action and unprecedented molecular structures, have prompted an intense research activity directed towards their total syntheses, analogue design, and biological evaluations for their development as new anticancer agents. Together with these biological studies in cancer research, in recent years, the bengamides have been identified as potential antibiotics by their impressive biological activities against various drug-resistant bacteria such as Mycobacterium tuberculosis and Staphylococcus aureus. This review reports on the new advances in the chemistry and biology of the bengamides during the last years, paying special attention to their development as promising new antibiotics. Thus, the evolution of the bengamides from their initial exploration as antitumor agents up to their current status as antibiotics is described in detail, highlighting the manifold value of these marine natural products as valid hits in medicinal chemistry.
KW - antibiotics
KW - antitumor agents
KW - bengamides
KW - drug-resistant bacteria
KW - SAR
UR - http://www.scopus.com/inward/record.url?scp=85132289520&partnerID=8YFLogxK
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U2 - 10.3390/md20060373
DO - 10.3390/md20060373
M3 - Review article
C2 - 35736176
AN - SCOPUS:85132289520
VL - 20
JO - Marine Drugs
JF - Marine Drugs
SN - 1660-3397
IS - 6
M1 - 373
ER -
