The development of multisensory integration in high-functioning autism: High-density electrical mapping and psychophysical measures reveal impairments in the processing of audiovisual inputs

Alice B. Brandwein, John J. Foxe, John S. Butler, Natalie N. Russo, Ted S. Altschuler, Hilary Gomes, Sophie Molholm

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

Successful integration of auditory and visual inputs is crucial for both basic perceptual functions and for higher-order processes related to social cognition. Autism spectrum disorders (ASD) are characterized by impairments in social cognition and are associated with abnormalities in sensory and perceptual processes. Several groups have reported that individuals with ASD are impaired in their ability to integrate socially relevant audiovisual (AV) information, and it has been suggested that this contributes to the higher-order social and cognitive deficits observed in ASD. However, successful integration of auditory and visual inputs also influences detection and perception of nonsocial stimuli, and integration deficits may impair earlier stages of information processing, with cascading downstream effects. To assess the integrity of basic AV integration, we recorded high-density electrophysiology from a cohort of high-functioning children with ASD (7-16 years) while they performed a simple AV reaction time task. Children with ASD showed considerably less behavioral facilitation to multisensory inputs, deficits that were paralleled by less effective neural integration. Evidence for processing differences relative to typically developing children was seen as early as 100 ms poststimulation, and topographic analysis suggested that children with ASD relied on different cortical networks during this early multisensory processing stage.

Original languageEnglish (US)
Pages (from-to)1329-1341
Number of pages13
JournalCerebral Cortex
Volume23
Issue number6
DOIs
StatePublished - Jun 2013
Externally publishedYes

Fingerprint

Autistic Disorder
Cognition
Aptitude
Electrophysiology
Automatic Data Processing
Reaction Time
Autism Spectrum Disorder

Keywords

  • auditory
  • electrophysiology
  • ERPs
  • multimodal
  • visual

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

The development of multisensory integration in high-functioning autism : High-density electrical mapping and psychophysical measures reveal impairments in the processing of audiovisual inputs. / Brandwein, Alice B.; Foxe, John J.; Butler, John S.; Russo, Natalie N.; Altschuler, Ted S.; Gomes, Hilary; Molholm, Sophie.

In: Cerebral Cortex, Vol. 23, No. 6, 06.2013, p. 1329-1341.

Research output: Contribution to journalArticle

Brandwein, Alice B. ; Foxe, John J. ; Butler, John S. ; Russo, Natalie N. ; Altschuler, Ted S. ; Gomes, Hilary ; Molholm, Sophie. / The development of multisensory integration in high-functioning autism : High-density electrical mapping and psychophysical measures reveal impairments in the processing of audiovisual inputs. In: Cerebral Cortex. 2013 ; Vol. 23, No. 6. pp. 1329-1341.
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