The detection of mediastinal parathyroid glands by computed tomography, selective arteriography, and venous sampling. An analysis of 17 cases

A. G. Krudy, J. L. Doppman, M. F. Brennan, S. J. Marx, Allen M. Spiegel, J. L. Stock, G. D. Aurbach

Research output: Contribution to journalArticle

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Abstract

Computed tomography (CT) scans were reviewed in 19 cases of proved mediastinal parathyroid glands. Glands were detected in five of 17 cases (29%) with adquate scans; four of six (67%) anterior mediastinal glands larger than 2 cm were visible. The smallest lesion demonstrated by CT was 1.6 cm. In the same series, selective arteriography was positive in 10 of 15 cases (67%), with the smallest lesion measuring 0.5 cm. Venous sampling was performed in 15 patients, and a thymic sample obtained in 10; a twofold step-up of parathyroid hormone in thymic veins was noted in eight of 15 cases (53%), but was not localizing, as samples in other veins were elevated in all but one case. Angiography appears more sensitive than second-generation CT for detecting mediastinal glands. However, CT is very useful in patients with previous failed explorations. Scanning must include contiguous sections extending several centimeters below the carina, in order to encompass low-lying mediastinal glands.

Original languageEnglish (US)
Pages (from-to)739-744
Number of pages6
JournalRadiology
Volume140
Issue number3
StatePublished - 1981
Externally publishedYes

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Parathyroid Glands
Angiography
Tomography
Veins
Parathyroid Hormone

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Krudy, A. G., Doppman, J. L., Brennan, M. F., Marx, S. J., Spiegel, A. M., Stock, J. L., & Aurbach, G. D. (1981). The detection of mediastinal parathyroid glands by computed tomography, selective arteriography, and venous sampling. An analysis of 17 cases. Radiology, 140(3), 739-744.

The detection of mediastinal parathyroid glands by computed tomography, selective arteriography, and venous sampling. An analysis of 17 cases. / Krudy, A. G.; Doppman, J. L.; Brennan, M. F.; Marx, S. J.; Spiegel, Allen M.; Stock, J. L.; Aurbach, G. D.

In: Radiology, Vol. 140, No. 3, 1981, p. 739-744.

Research output: Contribution to journalArticle

Krudy, AG, Doppman, JL, Brennan, MF, Marx, SJ, Spiegel, AM, Stock, JL & Aurbach, GD 1981, 'The detection of mediastinal parathyroid glands by computed tomography, selective arteriography, and venous sampling. An analysis of 17 cases', Radiology, vol. 140, no. 3, pp. 739-744.
Krudy, A. G. ; Doppman, J. L. ; Brennan, M. F. ; Marx, S. J. ; Spiegel, Allen M. ; Stock, J. L. ; Aurbach, G. D. / The detection of mediastinal parathyroid glands by computed tomography, selective arteriography, and venous sampling. An analysis of 17 cases. In: Radiology. 1981 ; Vol. 140, No. 3. pp. 739-744.
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AU - Spiegel, Allen M.

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AU - Aurbach, G. D.

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AB - Computed tomography (CT) scans were reviewed in 19 cases of proved mediastinal parathyroid glands. Glands were detected in five of 17 cases (29%) with adquate scans; four of six (67%) anterior mediastinal glands larger than 2 cm were visible. The smallest lesion demonstrated by CT was 1.6 cm. In the same series, selective arteriography was positive in 10 of 15 cases (67%), with the smallest lesion measuring 0.5 cm. Venous sampling was performed in 15 patients, and a thymic sample obtained in 10; a twofold step-up of parathyroid hormone in thymic veins was noted in eight of 15 cases (53%), but was not localizing, as samples in other veins were elevated in all but one case. Angiography appears more sensitive than second-generation CT for detecting mediastinal glands. However, CT is very useful in patients with previous failed explorations. Scanning must include contiguous sections extending several centimeters below the carina, in order to encompass low-lying mediastinal glands.

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