The deployment of intersensory selective attention: A high-density electrical mapping study of the effects of theanine

Manuel Gomez-Ramirez, Beth A. Higgins, Jane A. Rycroft, Gail N. Owen, Jeannette R. Mahoney, Marina Shpaner, John J. Foxe

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

OBJECTIVE: Ingestion of the nonproteinic amino acid theanine (5-N-ethylglutamine) has been shown to increase oscillatory brain activity in the so-called alpha band (8-14 Hz) during resting electroencephalographic recordings in humans. Independently, alpha band activity has been shown to be a key component in selective attentional processes. Here, we set out to assess whether theanine would cause modulation of anticipatory alpha activity during selective attentional deployments to stimuli in different sensory modalities, a paradigm in which robust alpha attention effects have previously been established. METHODS: Electrophysiological data from 168 scalp electrode channels were recorded while participants performed a standard intersensory attentional cuing task. RESULTS: As in previous studies, significantly greater alpha band activity was measured over parieto-occipital scalp for attentional deployments to the auditory modality than to the visual modality. Theanine ingestion resulted in a substantial overall decrease in background alpha levels relative to placebo while subjects were actively performing this demanding attention task. Despite this decrease in background alpha activity, attention-related alpha effects were significantly greater for the theanine condition. CONCLUSION: This increase of attention-related anticipatory alpha over the right parieto-occipital scalp suggests that theanine may have a specific effect on the brain's attention circuitry. We conclude that theanine has clear psychoactive properties, and that it represents a potentially interesting, naturally occurring compound for further study, as it relates to the brain's attentional system.

Original languageEnglish (US)
Pages (from-to)25-38
Number of pages14
JournalClinical Neuropharmacology
Volume30
Issue number1
DOIs
StatePublished - Jan 2007

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Scalp
Brain
Eating
theanine
Electrodes
Placebos
Amino Acids

Keywords

  • Alpha oscillations
  • Attention
  • Attentional deployment
  • EEG
  • Multisensory
  • Theanine

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Clinical Neurology
  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

The deployment of intersensory selective attention : A high-density electrical mapping study of the effects of theanine. / Gomez-Ramirez, Manuel; Higgins, Beth A.; Rycroft, Jane A.; Owen, Gail N.; Mahoney, Jeannette R.; Shpaner, Marina; Foxe, John J.

In: Clinical Neuropharmacology, Vol. 30, No. 1, 01.2007, p. 25-38.

Research output: Contribution to journalArticle

Gomez-Ramirez, Manuel ; Higgins, Beth A. ; Rycroft, Jane A. ; Owen, Gail N. ; Mahoney, Jeannette R. ; Shpaner, Marina ; Foxe, John J. / The deployment of intersensory selective attention : A high-density electrical mapping study of the effects of theanine. In: Clinical Neuropharmacology. 2007 ; Vol. 30, No. 1. pp. 25-38.
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