The demographic and biomedical case for late-life interventions in aging

Michael J. Rae, Robert N. Butler, Judith Campisi, Aubrey D.N.J. De Grey, Caleb E. Finch, Michael Gough, George M. Martin, Jan Vijg, Kevin M. Perrott, Barbara J. Logan

Research output: Contribution to journalComment/debate

59 Scopus citations


The social and medical costs of the biological aging process are high and will rise rapidly in coming decades, creating an enormous challenge to societies worldwide. In recent decades, researchers have expanded their understanding of the underlying deleterious structural and physiological changes (aging damage) that underlie the progressive functional impairments, declining health, and rising mortality of aging humans and other organisms and have been able to intervene in the process in model organisms, even late in life. To preempt a global aging crisis, we advocate an ambitious global initiative to translate these findings into interventions for aging humans, using three complementary approaches to retard, arrest, and even reverse aging damage, extending and even restoring the period of youthful health and functionality of older people.

Original languageEnglish (US)
Article number40cm21
JournalScience translational medicine
Issue number40
Publication statusPublished - Jul 14 2010


ASJC Scopus subject areas

  • Medicine(all)

Cite this

Rae, M. J., Butler, R. N., Campisi, J., De Grey, A. D. N. J., Finch, C. E., Gough, M., ... Logan, B. J. (2010). The demographic and biomedical case for late-life interventions in aging. Science translational medicine, 2(40), [40cm21].