The damage-response framework of microbial pathogenesis

Arturo Casadevall, Liise Anne Pirofski

Research output: Contribution to journalArticle

329 Scopus citations

Abstract

The late twentieth century witnessed the emergence of numerous infectious diseases that are caused by microorganisms that rarely cause disease in normal, healthy immunocompetent hosts. The emergence of these diseases shows that the existing concepts of pathogenicity and virulence do not take into account the fact that both the microorganism and the host contribute to microbial pathogenesis. To address this impediment to studies of host–microorganism interactions, we propose a new theoretical approach to understanding microbial pathogenesis, known as the 'damage-response' framework.

Original languageEnglish (US)
Pages (from-to)17-24
Number of pages8
JournalNature Reviews Microbiology
Volume1
Issue number1
DOIs
StatePublished - Oct 2003

ASJC Scopus subject areas

  • Microbiology
  • Immunology and Microbiology(all)
  • Infectious Diseases

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