The critical role of adrenomedullin and its binding protein, AMBP-1, in neuroprotection

Cletus Cheyuo, Weng Lang Yang, Ping Wang

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

Chronic neurodegenerative disorders and acute injuries of the central nervous system exert a prohibitive economic burden, which is aggravated by an unmet medical need for the development of effective neurotherapeutics. The evolutionarily conserved neuropeptide, adrenomedullin (AM), and its binding protein, AMBP-1, also known as complement factor H, play important roles in brain physiology, and their expression is altered in brain pathology. In this review, we discuss the molecular regulation of AM and AMBP-1 and the pivotal roles they play in neuroprotection following brain injury. We assess the reciprocal synergistic effects of AM and AMBP-1 and make suggestions for the design of a novel combination neurotherapy devoid of the potential hypotensive effects of AM while optimizing its neuroprotective property.

Original languageEnglish (US)
Pages (from-to)429-439
Number of pages11
JournalBiological Chemistry
Volume393
Issue number6
DOIs
StatePublished - May 2012
Externally publishedYes

Keywords

  • AMBP-1
  • adrenomedullin
  • apoptosis
  • inflammation
  • neurodegenerative disease
  • neuroprotection

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Clinical Biochemistry

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