The combination of pill count and self-reported adherence is a strong predictor of first-line art failure for adults in South Africa

Peng Wu, Brent A. Johnson, Jean B. Nachega, Baohua Wu, Claudia E. Ordonez, Anna Q. Hare, Rachel Kearns, Richard Murphy, Henry Sunpath, Vincent C. Marconi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Suboptimal adherence to antiretroviral therapy (ART) is a strong predictor of virologic failure (VF) among people with HIV. Various methods such as patient self-report, pill counts and pharmacy refills have been utilized to monitor adherence. However, there are limited data on the accuracy of combining methods to better predict VF in routine clinical settings. We examined various methods to assess adherence including pill count, medication possession ratio (MPR), and self-reported adherence in order to determine which was most highly associated with VF after > 6 months on ART.

Methods: We conducted a secondary analysis of data from a case-control study. At enrollment, pharmacy refill data were collected retrospectively from the medical chart, pill counts were completed to derive a pill count adherence ratio (PCAR) and a self-report questionnaire was administered to all participants. Parametric smooth splines and receiver operator characteristic (ROC) analyses were carried out to assess the accuracy of the adherence methods.

Results: 458 patients were enrolled from October 2010 to June 2012. Of these, 158 (34.50%) experienced VF (cases) and 300 (65.50%) were controls. The median (IQR) PCAR was 1.10 (0.99-1.14) for cases and 1.13 (1.08-1.18) for controls (p<0.0001). The median MPR was 1.00 (0.97-1.07) for cases and 1.03 (0.96-1.07) for controls (p=0.83). Combination of PCAR and self-reported questions was highly associated with VF.

Conclusion: In this setting, a combination of pill count adherence and self-report adherence questions had the highest diagnostic accuracy for VF. Further validation of this simple, low-cost combination is warranted in large prospective studies.

Original languageEnglish (US)
Pages (from-to)366-375
Number of pages10
JournalCurrent HIV Research
Volume12
Issue number5
StatePublished - Dec 1 2014

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Art
South Africa
Self Report
Case-Control Studies
HIV
Prospective Studies
Costs and Cost Analysis
Therapeutics

Keywords

  • Antiretroviral therapy
  • Medication possession ratio
  • Pill count adherence ratio
  • Self-reported adherence
  • South Africa
  • Virologic failure

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology
  • Medicine(all)

Cite this

Wu, P., Johnson, B. A., Nachega, J. B., Wu, B., Ordonez, C. E., Hare, A. Q., ... Marconi, V. C. (2014). The combination of pill count and self-reported adherence is a strong predictor of first-line art failure for adults in South Africa. Current HIV Research, 12(5), 366-375.

The combination of pill count and self-reported adherence is a strong predictor of first-line art failure for adults in South Africa. / Wu, Peng; Johnson, Brent A.; Nachega, Jean B.; Wu, Baohua; Ordonez, Claudia E.; Hare, Anna Q.; Kearns, Rachel; Murphy, Richard; Sunpath, Henry; Marconi, Vincent C.

In: Current HIV Research, Vol. 12, No. 5, 01.12.2014, p. 366-375.

Research output: Contribution to journalArticle

Wu, P, Johnson, BA, Nachega, JB, Wu, B, Ordonez, CE, Hare, AQ, Kearns, R, Murphy, R, Sunpath, H & Marconi, VC 2014, 'The combination of pill count and self-reported adherence is a strong predictor of first-line art failure for adults in South Africa', Current HIV Research, vol. 12, no. 5, pp. 366-375.
Wu, Peng ; Johnson, Brent A. ; Nachega, Jean B. ; Wu, Baohua ; Ordonez, Claudia E. ; Hare, Anna Q. ; Kearns, Rachel ; Murphy, Richard ; Sunpath, Henry ; Marconi, Vincent C. / The combination of pill count and self-reported adherence is a strong predictor of first-line art failure for adults in South Africa. In: Current HIV Research. 2014 ; Vol. 12, No. 5. pp. 366-375.
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abstract = "Background: Suboptimal adherence to antiretroviral therapy (ART) is a strong predictor of virologic failure (VF) among people with HIV. Various methods such as patient self-report, pill counts and pharmacy refills have been utilized to monitor adherence. However, there are limited data on the accuracy of combining methods to better predict VF in routine clinical settings. We examined various methods to assess adherence including pill count, medication possession ratio (MPR), and self-reported adherence in order to determine which was most highly associated with VF after > 6 months on ART.Methods: We conducted a secondary analysis of data from a case-control study. At enrollment, pharmacy refill data were collected retrospectively from the medical chart, pill counts were completed to derive a pill count adherence ratio (PCAR) and a self-report questionnaire was administered to all participants. Parametric smooth splines and receiver operator characteristic (ROC) analyses were carried out to assess the accuracy of the adherence methods.Results: 458 patients were enrolled from October 2010 to June 2012. Of these, 158 (34.50{\%}) experienced VF (cases) and 300 (65.50{\%}) were controls. The median (IQR) PCAR was 1.10 (0.99-1.14) for cases and 1.13 (1.08-1.18) for controls (p<0.0001). The median MPR was 1.00 (0.97-1.07) for cases and 1.03 (0.96-1.07) for controls (p=0.83). Combination of PCAR and self-reported questions was highly associated with VF.Conclusion: In this setting, a combination of pill count adherence and self-report adherence questions had the highest diagnostic accuracy for VF. Further validation of this simple, low-cost combination is warranted in large prospective studies.",
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AU - Wu, Peng

AU - Johnson, Brent A.

AU - Nachega, Jean B.

AU - Wu, Baohua

AU - Ordonez, Claudia E.

AU - Hare, Anna Q.

AU - Kearns, Rachel

AU - Murphy, Richard

AU - Sunpath, Henry

AU - Marconi, Vincent C.

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N2 - Background: Suboptimal adherence to antiretroviral therapy (ART) is a strong predictor of virologic failure (VF) among people with HIV. Various methods such as patient self-report, pill counts and pharmacy refills have been utilized to monitor adherence. However, there are limited data on the accuracy of combining methods to better predict VF in routine clinical settings. We examined various methods to assess adherence including pill count, medication possession ratio (MPR), and self-reported adherence in order to determine which was most highly associated with VF after > 6 months on ART.Methods: We conducted a secondary analysis of data from a case-control study. At enrollment, pharmacy refill data were collected retrospectively from the medical chart, pill counts were completed to derive a pill count adherence ratio (PCAR) and a self-report questionnaire was administered to all participants. Parametric smooth splines and receiver operator characteristic (ROC) analyses were carried out to assess the accuracy of the adherence methods.Results: 458 patients were enrolled from October 2010 to June 2012. Of these, 158 (34.50%) experienced VF (cases) and 300 (65.50%) were controls. The median (IQR) PCAR was 1.10 (0.99-1.14) for cases and 1.13 (1.08-1.18) for controls (p<0.0001). The median MPR was 1.00 (0.97-1.07) for cases and 1.03 (0.96-1.07) for controls (p=0.83). Combination of PCAR and self-reported questions was highly associated with VF.Conclusion: In this setting, a combination of pill count adherence and self-report adherence questions had the highest diagnostic accuracy for VF. Further validation of this simple, low-cost combination is warranted in large prospective studies.

AB - Background: Suboptimal adherence to antiretroviral therapy (ART) is a strong predictor of virologic failure (VF) among people with HIV. Various methods such as patient self-report, pill counts and pharmacy refills have been utilized to monitor adherence. However, there are limited data on the accuracy of combining methods to better predict VF in routine clinical settings. We examined various methods to assess adherence including pill count, medication possession ratio (MPR), and self-reported adherence in order to determine which was most highly associated with VF after > 6 months on ART.Methods: We conducted a secondary analysis of data from a case-control study. At enrollment, pharmacy refill data were collected retrospectively from the medical chart, pill counts were completed to derive a pill count adherence ratio (PCAR) and a self-report questionnaire was administered to all participants. Parametric smooth splines and receiver operator characteristic (ROC) analyses were carried out to assess the accuracy of the adherence methods.Results: 458 patients were enrolled from October 2010 to June 2012. Of these, 158 (34.50%) experienced VF (cases) and 300 (65.50%) were controls. The median (IQR) PCAR was 1.10 (0.99-1.14) for cases and 1.13 (1.08-1.18) for controls (p<0.0001). The median MPR was 1.00 (0.97-1.07) for cases and 1.03 (0.96-1.07) for controls (p=0.83). Combination of PCAR and self-reported questions was highly associated with VF.Conclusion: In this setting, a combination of pill count adherence and self-report adherence questions had the highest diagnostic accuracy for VF. Further validation of this simple, low-cost combination is warranted in large prospective studies.

KW - Antiretroviral therapy

KW - Medication possession ratio

KW - Pill count adherence ratio

KW - Self-reported adherence

KW - South Africa

KW - Virologic failure

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