The clinical and pathologic heterogeneity of feline alpha-mannosidosis.

J. F. Cummings, P. A. Wood, A. de Lahunta, Steven U. Walkley, L. Le Boeuf

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Three Domestic Long-haired cats from a litter of five afflicted with alpha-mannosidosis (alpha-mannosidosis) were studied clinically and pathologically. Many of these findings contrasted with those made previously in kittens with deficiency of alpha-mannosidase. In these cats, the clinical signs were generally milder, more slowly progressive, and did not include the prominent skeletal deformities, ocular abnormalities, or hepatomegaly that were reported in prior studies of Persian and Domestic Short-haired kittens. While the Domestic Long-haired cats were spared the central nervous system (CNS) myelin deficiency, which was severe in the Persian but mild in the Domestic Short-haired cats, the extensive loss of Purkinje cells in their cerebellar cortices was without precedent. Additionally, ultrastructural study of the neuronal cytosomes showed a diversity not recorded in the earlier cases. The observed phenotypic heterogeneity was sufficient enough to consider separating feline alpha-mannosidosis into severe, acute and milder, chronic forms in a manner analogous to the Type I and Type II distinctions made in infants and juveniles.

Original languageEnglish (US)
Pages (from-to)163-170
Number of pages8
JournalJournal of veterinary internal medicine / American College of Veterinary Internal Medicine
Volume2
Issue number4
StatePublished - Oct 1988

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alpha-mannosidosis
alpha-Mannosidosis
Felidae
Cats
cats
kittens
Eye Abnormalities
Cerebellar Cortex
Hepatomegaly
Purkinje Cells
alpha-mannosidase
Myelin Sheath
myelin sheath
Central Nervous System
litters (young animals)
central nervous system
cortex
eyes

ASJC Scopus subject areas

  • veterinary(all)

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The clinical and pathologic heterogeneity of feline alpha-mannosidosis. / Cummings, J. F.; Wood, P. A.; de Lahunta, A.; Walkley, Steven U.; Le Boeuf, L.

In: Journal of veterinary internal medicine / American College of Veterinary Internal Medicine, Vol. 2, No. 4, 10.1988, p. 163-170.

Research output: Contribution to journalArticle

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