The clavicle

a vulnerable bone in pediatric oncology.

H. Zietz, S. Berrak, H. Ried, K. Weber, M. Maor, N. Jaffe

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The clavicle is frequently incorporated into the radiation field in the treatment of malignant tumors located in the head and neck. From 1954 to 1995, 499 pediatric patients were treated with moderate to high-dose radiation therapy to the head and neck at the University of Texas M.D. Anderson Cancer Center. The medical records of 312 of these patients were available and were reviewed. The period of observation ranged from 5 to 30 years. Five late radiation-induced abnormalities of the clavicle were encountered: osteosarcoma; osteochondroma; malignant fibrous histiocytoma; radionecrosis and impaired healing following trauma and radionecrosis and lysis. The doses of radiation therapy which induced the abnormalities varied from 35 to 60.5 Gy (median 34.75 Gy). The interval from radiation therapy to discovery of the complications varied from 6 to 11 years. Two patients died: one from malignant fibrous histiocytoma and another from a radiation-induced meningioma of the brain (which accompanied radionecrosis of the clavicle). We conclude that the incidence of radiation-induced abnormalities of the clavicle in pediatric long-term survivors is low (1.5%). However, some of the late sequela are potentially fatal. The clavicle should be considered a vulnerable bone to radiation therapy and should be monitored in long-term survivors of childhood cancer. The experience is compared to radiation-induced abnormalities recorded in the literature.

Original languageEnglish (US)
Pages (from-to)689-695
Number of pages7
JournalInternational Journal of Oncology
Volume18
Issue number4
StatePublished - Apr 2001
Externally publishedYes

Fingerprint

Clavicle
Radiation-Induced Abnormalities
Pediatrics
Bone and Bones
Radiotherapy
Malignant Fibrous Histiocytoma
Survivors
Neck
Head
Osteochondroma
Neoplasms
Osteosarcoma
Medical Records
Observation
Radiation
Incidence
Wounds and Injuries
Brain

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Zietz, H., Berrak, S., Ried, H., Weber, K., Maor, M., & Jaffe, N. (2001). The clavicle: a vulnerable bone in pediatric oncology. International Journal of Oncology, 18(4), 689-695.

The clavicle : a vulnerable bone in pediatric oncology. / Zietz, H.; Berrak, S.; Ried, H.; Weber, K.; Maor, M.; Jaffe, N.

In: International Journal of Oncology, Vol. 18, No. 4, 04.2001, p. 689-695.

Research output: Contribution to journalArticle

Zietz, H, Berrak, S, Ried, H, Weber, K, Maor, M & Jaffe, N 2001, 'The clavicle: a vulnerable bone in pediatric oncology.', International Journal of Oncology, vol. 18, no. 4, pp. 689-695.
Zietz H, Berrak S, Ried H, Weber K, Maor M, Jaffe N. The clavicle: a vulnerable bone in pediatric oncology. International Journal of Oncology. 2001 Apr;18(4):689-695.
Zietz, H. ; Berrak, S. ; Ried, H. ; Weber, K. ; Maor, M. ; Jaffe, N. / The clavicle : a vulnerable bone in pediatric oncology. In: International Journal of Oncology. 2001 ; Vol. 18, No. 4. pp. 689-695.
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