The chiral pyrethroid cycloprothrin: Stereoisomer synthesis and separation and stereoselective insecticidal activity

Biao Jiang, Hua Wang, Qun Mei Fu, Zhu Yi Li

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The synthesis and separation of the isomers of the pesticide cycloprothrin have been realized for the first time. Complete separation was achieved on a DAICEL CHIRALCEL® OJ-H column (25 x 0.46 cm) for (1R, a*)- cycloprothrin isomers and on a DAICEL CHIRALCEL OD-H column (25 x 0.46 cm) for (1S, a*)-cycloprothrin isomers. The insecticidal activity of (1R, αR)-cycloprothrin for the larvae of Mythimaseparata and Aphismedicagini was found to be about six times and four times higher, respectively, than that of racemic cycloprothrin.

Original languageEnglish (US)
Pages (from-to)96-102
Number of pages7
JournalChirality
Volume20
Issue number2
DOIs
StatePublished - Feb 2008
Externally publishedYes

Fingerprint

Pyrethrins
Stereoisomerism
Isomers
Thermodynamic properties
Pesticides
Larva
cycloprothrin

Keywords

  • Chiral cycloprothrin
  • Chiral separation
  • Insecticidal activity
  • Pyrethroid

ASJC Scopus subject areas

  • Analytical Chemistry
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

The chiral pyrethroid cycloprothrin : Stereoisomer synthesis and separation and stereoselective insecticidal activity. / Jiang, Biao; Wang, Hua; Fu, Qun Mei; Li, Zhu Yi.

In: Chirality, Vol. 20, No. 2, 02.2008, p. 96-102.

Research output: Contribution to journalArticle

Jiang, Biao ; Wang, Hua ; Fu, Qun Mei ; Li, Zhu Yi. / The chiral pyrethroid cycloprothrin : Stereoisomer synthesis and separation and stereoselective insecticidal activity. In: Chirality. 2008 ; Vol. 20, No. 2. pp. 96-102.
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