The chiral pyrethroid cycloprothrin: Stereoisomer synthesis and separation and stereoselective insecticidal activity

Biao Jiang, Hua Wang, Qun Mei Fu, Zhu Yi Li

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

The synthesis and separation of the isomers of the pesticide cycloprothrin have been realized for the first time. Complete separation was achieved on a DAICEL CHIRALCEL® OJ-H column (25 x 0.46 cm) for (1R, a*)- cycloprothrin isomers and on a DAICEL CHIRALCEL OD-H column (25 x 0.46 cm) for (1S, a*)-cycloprothrin isomers. The insecticidal activity of (1R, αR)-cycloprothrin for the larvae of Mythimaseparata and Aphismedicagini was found to be about six times and four times higher, respectively, than that of racemic cycloprothrin.

Original languageEnglish (US)
Pages (from-to)96-102
Number of pages7
JournalChirality
Volume20
Issue number2
DOIs
StatePublished - Feb 1 2008

Keywords

  • Chiral cycloprothrin
  • Chiral separation
  • Insecticidal activity
  • Pyrethroid

ASJC Scopus subject areas

  • Analytical Chemistry
  • Catalysis
  • Pharmacology
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

Fingerprint Dive into the research topics of 'The chiral pyrethroid cycloprothrin: Stereoisomer synthesis and separation and stereoselective insecticidal activity'. Together they form a unique fingerprint.

  • Cite this