Abstract
With the worldwide emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis (Mtb), there are serious concerns about the continued ability to contain this disease. We discuss the most promising new drugs in late-stage development that might be useful in treating MDR and XDR forms of the disease. These agents have novel mechanisms of action that are not targeted by the standard drugs used presently to treat susceptible strains.
Original language | English (US) |
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Pages (from-to) | 456-466 |
Number of pages | 11 |
Journal | Current Opinion in Chemical Biology |
Volume | 14 |
Issue number | 4 |
DOIs | |
State | Published - Aug 2010 |
ASJC Scopus subject areas
- Analytical Chemistry
- Biochemistry