The chemical biology of new drugs in the development for tuberculosis

Clifton E. Barry, John S. Blanchard

Research output: Contribution to journalReview article

46 Scopus citations

Abstract

With the worldwide emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis (Mtb), there are serious concerns about the continued ability to contain this disease. We discuss the most promising new drugs in late-stage development that might be useful in treating MDR and XDR forms of the disease. These agents have novel mechanisms of action that are not targeted by the standard drugs used presently to treat susceptible strains.

Original languageEnglish (US)
Pages (from-to)456-466
Number of pages11
JournalCurrent Opinion in Chemical Biology
Volume14
Issue number4
DOIs
StatePublished - Aug 1 2010

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

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