The chemical biology of new drugs in the development for tuberculosis

Clifton E. Barry, John S. Blanchard

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

With the worldwide emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis (Mtb), there are serious concerns about the continued ability to contain this disease. We discuss the most promising new drugs in late-stage development that might be useful in treating MDR and XDR forms of the disease. These agents have novel mechanisms of action that are not targeted by the standard drugs used presently to treat susceptible strains.

Original languageEnglish (US)
Pages (from-to)456-466
Number of pages11
JournalCurrent Opinion in Chemical Biology
Volume14
Issue number4
DOIs
StatePublished - Aug 2010

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Tuberculosis
Pharmaceutical Preparations
Mycobacterium tuberculosis

ASJC Scopus subject areas

  • Biochemistry
  • Analytical Chemistry

Cite this

The chemical biology of new drugs in the development for tuberculosis. / Barry, Clifton E.; Blanchard, John S.

In: Current Opinion in Chemical Biology, Vol. 14, No. 4, 08.2010, p. 456-466.

Research output: Contribution to journalArticle

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