Natural killer T (NKT) cells play an important role in controlling cancers, infectious diseases and autoimmune diseases. Although the rhesus macaque is a useful primate model for many human diseases such as infectious and autoimmune diseases, little is known about their NKT cells. We analyzed Vα24TCR+ T cells from rhesus macaque peripheral blood mononuclear cells stimulated with α-galactosylceramide (α-GalCer) and interleukin-2. We found that rhesus macaques possess Vα24TCR+ T cells, suggesting that recognition of α-GalCer is highly conserved between rhesus macaques and humans. The amino acid sequences of the V-J junction for the Vα24TCR of rhesus macaque and human NKT cells are highly conserved (93% similarity), and the CD1d α1-α2 domains of both species are highly homologous (95.6%). These findings indicate that the rhesus macaque is a useful primate model for understanding the contribution of NKT cells to the control of human diseases.
|Original language||English (US)|
|Number of pages||6|
|State||Published - Feb 1 2003|
- Nonhuman primate
- Rhesus macaque
ASJC Scopus subject areas