The CD1 family of lipid antigen-presenting molecules

Steven A. Porcelli, Brent W. Segelke, Masahiko Sugita, Ian A. Wilson, Michael B. Brenner

Research output: Contribution to journalArticle

144 Citations (Scopus)

Abstract

The paradigm that T cells recognize peptide antigens presented by major histocompatibility complex class I and class II molecules has been a guiding principle in the development of immunology. Here, Steven Porcelli and colleagues review studies that extend this paradigm by showing that CD1 proteins are a separate lineage of antigen-presenting molecules with unusually hydrophobic ligand-binding grooves that present nonpeptide lipid and glycolipid antigens to T cells.

Original languageEnglish (US)
Pages (from-to)362-367
Number of pages6
JournalImmunology Today
Volume19
Issue number8
DOIs
StatePublished - Aug 1 1998
Externally publishedYes

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Lipids
Antigens
T-Lymphocytes
Glycolipids
Allergy and Immunology
Major Histocompatibility Complex
Ligands
Peptides
Proteins

ASJC Scopus subject areas

  • Immunology

Cite this

Porcelli, S. A., Segelke, B. W., Sugita, M., Wilson, I. A., & Brenner, M. B. (1998). The CD1 family of lipid antigen-presenting molecules. Immunology Today, 19(8), 362-367. https://doi.org/10.1016/S0167-5699(98)01289-4

The CD1 family of lipid antigen-presenting molecules. / Porcelli, Steven A.; Segelke, Brent W.; Sugita, Masahiko; Wilson, Ian A.; Brenner, Michael B.

In: Immunology Today, Vol. 19, No. 8, 01.08.1998, p. 362-367.

Research output: Contribution to journalArticle

Porcelli, SA, Segelke, BW, Sugita, M, Wilson, IA & Brenner, MB 1998, 'The CD1 family of lipid antigen-presenting molecules', Immunology Today, vol. 19, no. 8, pp. 362-367. https://doi.org/10.1016/S0167-5699(98)01289-4
Porcelli, Steven A. ; Segelke, Brent W. ; Sugita, Masahiko ; Wilson, Ian A. ; Brenner, Michael B. / The CD1 family of lipid antigen-presenting molecules. In: Immunology Today. 1998 ; Vol. 19, No. 8. pp. 362-367.
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