The CD1 family of lipid antigen-presenting molecules

Steven A. Porcelli, Brent W. Segelke, Masahiko Sugita, Ian A. Wilson, Michael B. Brenner

Research output: Contribution to journalReview article

145 Scopus citations

Abstract

The paradigm that T cells recognize peptide antigens presented by major histocompatibility complex class I and class II molecules has been a guiding principle in the development of immunology. Here, Steven Porcelli and colleagues review studies that extend this paradigm by showing that CD1 proteins are a separate lineage of antigen-presenting molecules with unusually hydrophobic ligand-binding grooves that present nonpeptide lipid and glycolipid antigens to T cells.

Original languageEnglish (US)
Pages (from-to)362-368
Number of pages7
JournalImmunology Today
Volume19
Issue number8
DOIs
StatePublished - Aug 1 1998
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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    Porcelli, S. A., Segelke, B. W., Sugita, M., Wilson, I. A., & Brenner, M. B. (1998). The CD1 family of lipid antigen-presenting molecules. Immunology Today, 19(8), 362-368. https://doi.org/10.1016/S0167-5699(98)01289-4