The CD1 family and T cell recognition of lipid antigens

Y. Dutronc, Steven A. Porcelli

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

For many years it was thought that T lymphocytes recognized only peptide antigens presented by MHC class I or class II molecules. Recently, it has become clear that a wide variety of lipids and glycolipids are also targets of the T cell response. This novel form of cell-mediated immune recognition is mediated by a family of lipid binding and presenting molecules known as CD1. The CD1 proteins represent a small to moderate sized family of β2-microglobulin-associated transmembrane proteins that are distantly related to MHC class I and class II molecules. They are conserved in most or all mammals, and control the development and function of T cell populations that participate in innate and adaptive immune responses through the recognition of self and foreign lipid antigens. Here we review the current state of our understanding of the structure and function of CD1 proteins, and the role of CD1-restricted T cell responses in the immune system.

Original languageEnglish (US)
Pages (from-to)337-353
Number of pages17
JournalTissue Antigens
Volume60
Issue number5
DOIs
StatePublished - Nov 1 2002

Fingerprint

T-Lymphocytes
Lipids
Antigens
Proteins
Glycolipids
Adaptive Immunity
Innate Immunity
Mammals
Immune System
Peptides
Population

Keywords

  • Adaptive immunity
  • CD1
  • Glycolipid
  • Innate immunity
  • Lipid
  • NK T cell
  • T cell

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

Cite this

The CD1 family and T cell recognition of lipid antigens. / Dutronc, Y.; Porcelli, Steven A.

In: Tissue Antigens, Vol. 60, No. 5, 01.11.2002, p. 337-353.

Research output: Contribution to journalArticle

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