The benefits of using selenium in the treatment of Chagas disease: Prevention of right ventricle chamber dilatation and reversion of Trypanosoma cruzi-induced acute and chronic cardiomyopathy in mice

Andréa P. de Souza, Linda A. Jelicks, Herbert B. Tanowitz, Bianca P. Olivieri, Monica M. Medeiros, Gabriel M. Oliveira, Andrea Rodrigues Cordovil Pires, Alessandro M. Dos Santos, Tania C. Araújo-Jorge

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Cardiac damage is a frequent manifestation of Chagas disease, which is caused by the parasite Trypanosoma cruzi. Selenium (Se) is an essential micronutrient, the deficiency of which has been implicated in the development of cardiomyopathy. Our group has previously demonstrated that Se supplementation prevents myocardial damage during acute T. cruzi infection in mice. In this study, we analyzed the effect of Se treatment in cases of T. cruzi infection using prevention and reversion schemes. In the Se prevention scheme, mice were given Se supplements (2 ppm) starting two weeks prior to inoculation with T. cruzi (Brazil strain) and continuing until 120 days post-infection (dpi). In the Se reversion scheme, mice were treated with Se (4 ppm) for 100 days, starting at 160 dpi. Dilatation of the right ventricle was observed in the infected control group at both phases of T. cruzi infection, but it was not observed in the infected group that received Se treatment. Surviving infected mice that were submitted to the Se reversion scheme presented normal P wave values and reduced inflammation of the pericardium. These data indicate that Se treatment prevents right ventricular chamber increase and thus can be proposed as an adjuvant therapy for cardiac alterations already established by T. cruzi infection.

Original languageEnglish (US)
Pages (from-to)746-751
Number of pages6
JournalMemorias do Instituto Oswaldo Cruz
Volume105
Issue number6
StatePublished - Sep 2010

Fingerprint

Chagas Disease
Trypanosoma cruzi
Selenium
Cardiomyopathies
Heart Ventricles
Dilatation
Infection
Micronutrients
Pericardium
Brazil
Parasites
Inflammation
Control Groups

Keywords

  • Cardiomyopathy
  • Chagas disease
  • Selenium
  • Trypanosoma cruzi

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

The benefits of using selenium in the treatment of Chagas disease : Prevention of right ventricle chamber dilatation and reversion of Trypanosoma cruzi-induced acute and chronic cardiomyopathy in mice. / de Souza, Andréa P.; Jelicks, Linda A.; Tanowitz, Herbert B.; Olivieri, Bianca P.; Medeiros, Monica M.; Oliveira, Gabriel M.; Pires, Andrea Rodrigues Cordovil; Dos Santos, Alessandro M.; Araújo-Jorge, Tania C.

In: Memorias do Instituto Oswaldo Cruz, Vol. 105, No. 6, 09.2010, p. 746-751.

Research output: Contribution to journalArticle

de Souza, AP, Jelicks, LA, Tanowitz, HB, Olivieri, BP, Medeiros, MM, Oliveira, GM, Pires, ARC, Dos Santos, AM & Araújo-Jorge, TC 2010, 'The benefits of using selenium in the treatment of Chagas disease: Prevention of right ventricle chamber dilatation and reversion of Trypanosoma cruzi-induced acute and chronic cardiomyopathy in mice', Memorias do Instituto Oswaldo Cruz, vol. 105, no. 6, pp. 746-751.
de Souza, Andréa P. ; Jelicks, Linda A. ; Tanowitz, Herbert B. ; Olivieri, Bianca P. ; Medeiros, Monica M. ; Oliveira, Gabriel M. ; Pires, Andrea Rodrigues Cordovil ; Dos Santos, Alessandro M. ; Araújo-Jorge, Tania C. / The benefits of using selenium in the treatment of Chagas disease : Prevention of right ventricle chamber dilatation and reversion of Trypanosoma cruzi-induced acute and chronic cardiomyopathy in mice. In: Memorias do Instituto Oswaldo Cruz. 2010 ; Vol. 105, No. 6. pp. 746-751.
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