The beginning of connectomics: a commentary on White et al. (1986) 'The structure of the nervous system of the nematode Caenorhabditis elegans'

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Abstract

The article 'Structure of the nervous system of the nematode Caenorhabditis elegans' (aka 'The mind of a worm') by White et al., published for the first time the complete set of synaptic connections in the nervous system of an animal. The work was carried out as part of a programme to begin to understand how genes determine the structure of a nervous system and how a nervous system creates behaviour. It became a major stimulus to the field of C. elegans research, which has since contributed insights into all areas of biology. Twenty-six years elapsed before developments, notably more powerful computers, made new studies of this kind possible. It is hoped that one day knowledge of synaptic structure, the connectome, together with results of many other investigations, will lead to an understanding of the human brain. This commentary was written to celebrate the 350th anniversary of the journal Philosophical Transactions of the Royal Society.

Original languageEnglish (US)
JournalPhilosophical transactions of the Royal Society of London. Series B, Biological sciences
Volume370
Issue number1666
DOIs
StatePublished - Apr 19 2015

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Connectome
Caenorhabditis elegans
Neurology
nervous system
Nervous System
nematode
Nematoda
Anniversaries and Special Events
brain
Brain
Animals
Genes
Biological Sciences
gene
animal
Research
animals
genes

Keywords

  • Caenorhabditis elegans
  • connectomics
  • nervous system

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

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