The BCL2-family of protein ligands as cancer drugs: The next generation of therapeutics

Wen Jing Liu, Anca Bulgaru, Missak Haigentz, C. A. Stein, Roman Perez-Soler, Sridhar Mani

Research output: Contribution to journalReview article

39 Scopus citations

Abstract

Selective aberrant cell suicide (ie., apoptosis or programmed cell death) is a hallmark of "nonneoplastic" tissue. In cells that have clonally evolved or in common parlance "cancer cells", apoptosis is either itself aberrant or completely inhibited. Strategies to enhance apoptosis under conditions of cancer cellular stress is an evolving and actively investigated area of experimental therapeutics. Bcl2 proteins are key mediators of the process of apoptosis and ligands to these family of proteins have been described using modern combinatorial, computational and evolutionary small molecule screening approaches. Crystallization of several of the Bcl2 family members has provided clarification of the role of these ligands and provided a clearer mechanism of action for the consequences of ligand binding. In several cases, these ligands (e.g., HA14-1, 2-methoxy antimycin A) induce apoptosis even under conditions of Bcl2 overexpression and if developed preclinically will be promising anticancer agents. This rationale becomes even more striking when one observes overexpression of Bcl2 in 70% of breast cancer, 30-60% of prostate cancer, 80% of B-cell lymphomas, 90% of colorectal adenocarcinomas, and many other forms of cancer.

Original languageEnglish (US)
Pages (from-to)217-223
Number of pages7
JournalCurrent Medicinal Chemistry - Anti-Cancer Agents
Volume3
Issue number3
DOIs
StatePublished - May 7 2003

Keywords

  • Apoptosis
  • Bcl-x
  • Bcl2 ligands
  • Cell death
  • Chemical structures
  • HA14-1

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Cancer Research

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