The association study of the DRD2 gene C939T polymorphism and schizophrenia

M. V. Monakhov, V. E. Golimbet, K. V. Chubabria, V. V. Zykov, A. L. Kovtun, V. L. Karpov

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Physiological evidences and several association studies suggest that the DRD2 gene is implicated in the pathogenesis of schizophrenia. The DRD2 C939T (rs6275) single nucleotide polymorphism was genotyped in 272 patients and 362 healthy controls. An association between this polymorphism and schizophrenia was found (p=0,02), the frequency of the TT genotype being higher in patients compared to the controls (χ2=7,2; p=0,007; OR=1,96, 95% Cl=1,2-3,2). The results obtained replicate the data of a previous study of the association between the T allele and schizophrenia.

Original languageEnglish (US)
Pages (from-to)58-60
Number of pages3
JournalZhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova
Volume107
Issue number10
StatePublished - Dec 17 2007
Externally publishedYes

Keywords

  • Association
  • DRD2 single nucleotide
  • Polimorphism
  • Schizophrenia

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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  • Cite this

    Monakhov, M. V., Golimbet, V. E., Chubabria, K. V., Zykov, V. V., Kovtun, A. L., & Karpov, V. L. (2007). The association study of the DRD2 gene C939T polymorphism and schizophrenia. Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova, 107(10), 58-60.