The association study of the DRD2 gene C939T polymorphism and schizophrenia

M. V. Monakhov; V. E. Golimbet; K. V. Chubabria; V. V. Zykov; A. L. Kovtun; V. L. Karpov

The association study of the DRD2 gene C939T polymorphism and schizophrenia

M. V. Monakhov, V. E. Golimbet, K. V. Chubabria, V. V. Zykov, A. L. Kovtun, V. L. Karpov

Research output: Contribution to journal › Article › peer-review

Abstract

Physiological evidences and several association studies suggest that the DRD2 gene is implicated in the pathogenesis of schizophrenia. The DRD2 C939T (rs6275) single nucleotide polymorphism was genotyped in 272 patients and 362 healthy controls. An association between this polymorphism and schizophrenia was found (p=0,02), the frequency of the TT genotype being higher in patients compared to the controls (χ²=7,2; p=0,007; OR=1,96, 95% Cl=1,2-3,2). The results obtained replicate the data of a previous study of the association between the T allele and schizophrenia.

Original language	English (US)
Pages (from-to)	58-60
Number of pages	3
Journal	Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova
Volume	107
Issue number	10
State	Published - 2007
Externally published	Yes

Keywords

Association
DRD2 single nucleotide
Polimorphism
Schizophrenia

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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abstract = "Physiological evidences and several association studies suggest that the DRD2 gene is implicated in the pathogenesis of schizophrenia. The DRD2 C939T (rs6275) single nucleotide polymorphism was genotyped in 272 patients and 362 healthy controls. An association between this polymorphism and schizophrenia was found (p=0,02), the frequency of the TT genotype being higher in patients compared to the controls (χ2=7,2; p=0,007; OR=1,96, 95% Cl=1,2-3,2). The results obtained replicate the data of a previous study of the association between the T allele and schizophrenia.",

keywords = "Association, DRD2 single nucleotide, Polimorphism, Schizophrenia",

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AU - Monakhov, M. V.

AU - Golimbet, V. E.

AU - Chubabria, K. V.

AU - Zykov, V. V.

AU - Kovtun, A. L.

AU - Karpov, V. L.

PY - 2007

Y1 - 2007

N2 - Physiological evidences and several association studies suggest that the DRD2 gene is implicated in the pathogenesis of schizophrenia. The DRD2 C939T (rs6275) single nucleotide polymorphism was genotyped in 272 patients and 362 healthy controls. An association between this polymorphism and schizophrenia was found (p=0,02), the frequency of the TT genotype being higher in patients compared to the controls (χ2=7,2; p=0,007; OR=1,96, 95% Cl=1,2-3,2). The results obtained replicate the data of a previous study of the association between the T allele and schizophrenia.

AB - Physiological evidences and several association studies suggest that the DRD2 gene is implicated in the pathogenesis of schizophrenia. The DRD2 C939T (rs6275) single nucleotide polymorphism was genotyped in 272 patients and 362 healthy controls. An association between this polymorphism and schizophrenia was found (p=0,02), the frequency of the TT genotype being higher in patients compared to the controls (χ2=7,2; p=0,007; OR=1,96, 95% Cl=1,2-3,2). The results obtained replicate the data of a previous study of the association between the T allele and schizophrenia.

KW - Association

KW - DRD2 single nucleotide

KW - Polimorphism

KW - Schizophrenia

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The association study of the DRD2 gene C939T polymorphism and schizophrenia

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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