The association of HIV status with bacterial vaginosis and vitamin D in the United States

Audrey L. French, Oluwatoyin M. Adeyemi, Denis M. Agniel, Charlesnika T. Evans, Michael T. Yin, Kathryn Anastos, Mardge H. Cohen

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objective: To estimate the association between vitamin D deficiency and bacterial vaginosis (BV) among nonpregnant HIV-infected and uninfected women. Methods: In a substudy of the Women's Interagency HIV Study, including women from Chicago and New York, the association between BV and vitamin D deficiency, demographics, and disease characteristics was tested using generalized estimating equations. Deficiency was defined as <20ng/mL 25 (OH) vitamin D and insufficiency as >20 and ≤30ng/mL. BV was defined by the Amsel criteria. Results: Among 602 observations of nonpregnant women (480 HIV infected and 122 uninfected), BV was found in 19%. Vitamin D deficiency was found in 59.4%, and insufficiency was found in 24.4%. In multivariable analysis, black race was the most significant predictor of BV (adjusted odds ratio [AOR] 5.90, (95% confidence interval [CI] 2.52-13.8). Vitamin D deficiency was independently associated with BV among HIV-infected women (AOR 3.12, 95% CI 1.16-8.38) but not among HIV-uninfected women. There was a negative linear correlation between vitamin D concentration and prevalence of BV in HIV-infected women (r=-0.15, p=0.001). Conclusions: Vitamin D deficiency was very common in this cohort and significantly associated with BV among HIV-infected women. These preliminary findings suggest that further epidemiologic and mechanistic exploration of the relationship between vitamin D and BV in HIV-infected women is warranted.

Original languageEnglish (US)
Pages (from-to)1497-1503
Number of pages7
JournalJournal of Women's Health
Volume20
Issue number10
DOIs
StatePublished - Oct 1 2011

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Bacterial Vaginosis
Vitamin D
HIV
Vitamin D Deficiency
Odds Ratio
Confidence Intervals
Deficiency Diseases
Demography

ASJC Scopus subject areas

  • Medicine(all)

Cite this

French, A. L., Adeyemi, O. M., Agniel, D. M., Evans, C. T., Yin, M. T., Anastos, K., & Cohen, M. H. (2011). The association of HIV status with bacterial vaginosis and vitamin D in the United States. Journal of Women's Health, 20(10), 1497-1503. https://doi.org/10.1089/jwh.2010.2685

The association of HIV status with bacterial vaginosis and vitamin D in the United States. / French, Audrey L.; Adeyemi, Oluwatoyin M.; Agniel, Denis M.; Evans, Charlesnika T.; Yin, Michael T.; Anastos, Kathryn; Cohen, Mardge H.

In: Journal of Women's Health, Vol. 20, No. 10, 01.10.2011, p. 1497-1503.

Research output: Contribution to journalArticle

French, AL, Adeyemi, OM, Agniel, DM, Evans, CT, Yin, MT, Anastos, K & Cohen, MH 2011, 'The association of HIV status with bacterial vaginosis and vitamin D in the United States', Journal of Women's Health, vol. 20, no. 10, pp. 1497-1503. https://doi.org/10.1089/jwh.2010.2685
French, Audrey L. ; Adeyemi, Oluwatoyin M. ; Agniel, Denis M. ; Evans, Charlesnika T. ; Yin, Michael T. ; Anastos, Kathryn ; Cohen, Mardge H. / The association of HIV status with bacterial vaginosis and vitamin D in the United States. In: Journal of Women's Health. 2011 ; Vol. 20, No. 10. pp. 1497-1503.
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