The association of depressive symptoms with inflammatory factors and adipokines in middle-aged and older Chinese

An Pan, Xingwang Ye, Oscar H. Fanco, Huaixing Li, Zhijie Yu, Jing Wang, Qibin Qi, Wenjia Gu, Xinghuo Pang, Hong Liu, Xu Lin

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Background. Studies in Western populations find that depression is associated with inflammation and obesity. The present study aimed to evaluate the relation of depressive symptoms with inflammatory factors and adipose-derived adipokines in middle-aged and older Chinese. Methodology/Principal Findings. Data were from 3289 community residents aged 50-70 from Beijing and Shanghai who participated in the Nutrition and Health of Aging Population in China project. Depressive symptoms were defined as a Center for Epidemiological Studies of Depression Scale (CES-D) score of 16 or higher. Plasma concentrations of C-reactive protein (CRP), interleukin-6 (IL-6), adiponectin, resistin, plasminogen activator inhibitor-1 (PAI-1) and retinol binding protein 4 (RBP4) were measured. Of the 3289 participants, 312 (9.5%) suffered from current depressive symptoms. IL-6 level was higher in participants with depressive symptoms compared to their counterparts in the crude analyses (1.17 vs. 1.05 pg/mL, p=0.023) and this association lost statistical significance after multiple adjustments (1.13 vs. 1.10 pg/mL, p=0.520). Depressive symptoms were not associated with increased mean levels of any other inflammatory factors or adipokines in the unadjusted or adjusted analyses. Conclusions/Significance. We found no evidence that depressive symptoms were associated with inflammatory factors and adipokines in the middle-aged and older Chinese populations. Prospective studies and studies in clinically diagnosed patients are needed to confirm our results and clarify the relation of depression with inflammatory factors and adipokines.

Original languageEnglish (US)
Article numbere1392
JournalPLoS One
Volume3
Issue number1
DOIs
StatePublished - Jan 2 2008
Externally publishedYes

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middle-aged adults
adipokines
Adipokines
signs and symptoms (animals and humans)
Depression
Interleukin-6
Resistin
interleukin-6
Retinol-Binding Proteins
China
Adiponectin
Plasminogen Activator Inhibitor 1
Nutrition
resistin
C-Reactive Protein
retinol-binding protein
adiponectin
Aging of materials
C-reactive protein
Health

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

The association of depressive symptoms with inflammatory factors and adipokines in middle-aged and older Chinese. / Pan, An; Ye, Xingwang; Fanco, Oscar H.; Li, Huaixing; Yu, Zhijie; Wang, Jing; Qi, Qibin; Gu, Wenjia; Pang, Xinghuo; Liu, Hong; Lin, Xu.

In: PLoS One, Vol. 3, No. 1, e1392, 02.01.2008.

Research output: Contribution to journalArticle

Pan, A, Ye, X, Fanco, OH, Li, H, Yu, Z, Wang, J, Qi, Q, Gu, W, Pang, X, Liu, H & Lin, X 2008, 'The association of depressive symptoms with inflammatory factors and adipokines in middle-aged and older Chinese', PLoS One, vol. 3, no. 1, e1392. https://doi.org/10.1371/journal.pone.0001392
Pan, An ; Ye, Xingwang ; Fanco, Oscar H. ; Li, Huaixing ; Yu, Zhijie ; Wang, Jing ; Qi, Qibin ; Gu, Wenjia ; Pang, Xinghuo ; Liu, Hong ; Lin, Xu. / The association of depressive symptoms with inflammatory factors and adipokines in middle-aged and older Chinese. In: PLoS One. 2008 ; Vol. 3, No. 1.
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abstract = "Background. Studies in Western populations find that depression is associated with inflammation and obesity. The present study aimed to evaluate the relation of depressive symptoms with inflammatory factors and adipose-derived adipokines in middle-aged and older Chinese. Methodology/Principal Findings. Data were from 3289 community residents aged 50-70 from Beijing and Shanghai who participated in the Nutrition and Health of Aging Population in China project. Depressive symptoms were defined as a Center for Epidemiological Studies of Depression Scale (CES-D) score of 16 or higher. Plasma concentrations of C-reactive protein (CRP), interleukin-6 (IL-6), adiponectin, resistin, plasminogen activator inhibitor-1 (PAI-1) and retinol binding protein 4 (RBP4) were measured. Of the 3289 participants, 312 (9.5{\%}) suffered from current depressive symptoms. IL-6 level was higher in participants with depressive symptoms compared to their counterparts in the crude analyses (1.17 vs. 1.05 pg/mL, p=0.023) and this association lost statistical significance after multiple adjustments (1.13 vs. 1.10 pg/mL, p=0.520). Depressive symptoms were not associated with increased mean levels of any other inflammatory factors or adipokines in the unadjusted or adjusted analyses. Conclusions/Significance. We found no evidence that depressive symptoms were associated with inflammatory factors and adipokines in the middle-aged and older Chinese populations. Prospective studies and studies in clinically diagnosed patients are needed to confirm our results and clarify the relation of depression with inflammatory factors and adipokines.",
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AB - Background. Studies in Western populations find that depression is associated with inflammation and obesity. The present study aimed to evaluate the relation of depressive symptoms with inflammatory factors and adipose-derived adipokines in middle-aged and older Chinese. Methodology/Principal Findings. Data were from 3289 community residents aged 50-70 from Beijing and Shanghai who participated in the Nutrition and Health of Aging Population in China project. Depressive symptoms were defined as a Center for Epidemiological Studies of Depression Scale (CES-D) score of 16 or higher. Plasma concentrations of C-reactive protein (CRP), interleukin-6 (IL-6), adiponectin, resistin, plasminogen activator inhibitor-1 (PAI-1) and retinol binding protein 4 (RBP4) were measured. Of the 3289 participants, 312 (9.5%) suffered from current depressive symptoms. IL-6 level was higher in participants with depressive symptoms compared to their counterparts in the crude analyses (1.17 vs. 1.05 pg/mL, p=0.023) and this association lost statistical significance after multiple adjustments (1.13 vs. 1.10 pg/mL, p=0.520). Depressive symptoms were not associated with increased mean levels of any other inflammatory factors or adipokines in the unadjusted or adjusted analyses. Conclusions/Significance. We found no evidence that depressive symptoms were associated with inflammatory factors and adipokines in the middle-aged and older Chinese populations. Prospective studies and studies in clinically diagnosed patients are needed to confirm our results and clarify the relation of depression with inflammatory factors and adipokines.

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