TY - JOUR
T1 - The association of cardiorespiratory fitness with cardiometabolic factors, markers of inflammation, and endothelial dysfunction in Latino youth
T2 - findings from the Hispanic Community Children's Health Study/Study of Latino Youth
AU - Isasi, Carmen R.
AU - Strizich, Garrett M.
AU - Kaplan, Robert
AU - Daviglus, Martha L.
AU - Sotres-Alvarez, Daniela
AU - Vidot, Denise C.
AU - Llabre, Maria M.
AU - Talavera, Gregory
AU - Carnethon, Mercedes R.
N1 - Funding Information:
The SOL Youth Study was supported by Grant number R01HL102130 from the National Heart, Lung, and Blood Institute. The children in SOL Youth are drawn from the study of adults: The Hispanic Children’s Community Health Study/Study of Latinos, which was supported by contracts from the National Heart, Lung, and Blood Institute (NHLBI) to the University of North Carolina (N01-HC65233), University of Miami (N01-HC65234), Albert Einstein College of Medicine (N01-HC65235), Northwestern University (N01-HC65236), and San Diego State University (N01-HC65237). The following Institutes/Centers/Offices contribute to the HCHS/SOL through a transfer of funds to NHLBI: National Center on Minority Health and Health Disparities, the National Institute of Deafness and Other Communications Disorders, the National Institute of Dental and Craniofacial Research, the National Institute of Diabetes and Digestive and Kidney Diseases, the National Institute of Neurological Disorders and Stroke, and the Office of Dietary Supplements. Additional support was provided by the Life Course Methodology Core of the New York Regional Center for Diabetes Translation Research (DK111022-8786). The study sponsors did not have any role in study design; collection, analysis, and interpretation of data; writing the report; and the decision to submit the report for publication. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Heart, Lung, and Blood Institute or the National Institutes of Health.
Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2018/9
Y1 - 2018/9
N2 - Purpose: To evaluate the relationship of cardiorespiratory fitness (CRF) with cardiovascular disease risk factors and a biomarker of endothelial dysfunction (e-selectin) among Hispanic/Latino youth. Methods: The study included 1380 Hispanic/Latino youths (8–16 years old) from the Hispanic Community Children's Health Study/Study of Latino Youth that enrolled from four cities (Bronx, Chicago, Miami, and San Diego). CRF was assessed by a 3-minute step test that uses postexercise heart rate to estimate maximal oxygen uptake. Regression models assessed differences in cardiometabolic markers across quartiles of CRF, adjusting for potential confounders. Results: CRF was higher among boys (mean: 57.6 mL per kg/min, 95% confidence interval, 56.8–58.4) compared to girls (mean: 54.7 mL per kg/min, 95% confidence interval, 53.9–55.5). Higher levels of CRF were associated with more favorable levels of cardiometabolic, inflammation, and endothelial dysfunction factors (P-values <.001) and independently of physical activity and sedentary time. Compared to the lowest quartile of CRF, the odds of having greater than or equal to two cardiovascular disease risk factors was lower at higher quartiles of CRF, after adjustment for potential confounders. Conclusions: Among Hispanic/Latino youth, CRF appears to be a strong protective factor for endothelial dysfunction and cardiometabolic risk factors. Strategies to improve CRF may be a useful approach for improving cardiovascular health in youth.
AB - Purpose: To evaluate the relationship of cardiorespiratory fitness (CRF) with cardiovascular disease risk factors and a biomarker of endothelial dysfunction (e-selectin) among Hispanic/Latino youth. Methods: The study included 1380 Hispanic/Latino youths (8–16 years old) from the Hispanic Community Children's Health Study/Study of Latino Youth that enrolled from four cities (Bronx, Chicago, Miami, and San Diego). CRF was assessed by a 3-minute step test that uses postexercise heart rate to estimate maximal oxygen uptake. Regression models assessed differences in cardiometabolic markers across quartiles of CRF, adjusting for potential confounders. Results: CRF was higher among boys (mean: 57.6 mL per kg/min, 95% confidence interval, 56.8–58.4) compared to girls (mean: 54.7 mL per kg/min, 95% confidence interval, 53.9–55.5). Higher levels of CRF were associated with more favorable levels of cardiometabolic, inflammation, and endothelial dysfunction factors (P-values <.001) and independently of physical activity and sedentary time. Compared to the lowest quartile of CRF, the odds of having greater than or equal to two cardiovascular disease risk factors was lower at higher quartiles of CRF, after adjustment for potential confounders. Conclusions: Among Hispanic/Latino youth, CRF appears to be a strong protective factor for endothelial dysfunction and cardiometabolic risk factors. Strategies to improve CRF may be a useful approach for improving cardiovascular health in youth.
KW - Cardiometabolic risk
KW - Cardiorrespiratory fitness
KW - Children
KW - Endothelial function
KW - Hispanic
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U2 - 10.1016/j.annepidem.2018.02.007
DO - 10.1016/j.annepidem.2018.02.007
M3 - Article
C2 - 29548689
AN - SCOPUS:85043481933
SN - 1047-2797
VL - 28
SP - 583-589.e3
JO - Annals of Epidemiology
JF - Annals of Epidemiology
IS - 9
ER -
