The association of cardiorespiratory fitness with cardiometabolic factors, markers of inflammation, and endothelial dysfunction in Latino youth: findings from the Hispanic Community Children's Health Study/Study of Latino Youth

Carmen R. Isasi, Garrett M. Strizich, Robert Kaplan, Martha L. Daviglus, Daniela Sotres-Alvarez, Denise C. Vidot, Maria M. Llabre, Gregory Talavera, Mercedes R. Carnethon

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Purpose: To evaluate the relationship of cardiorespiratory fitness (CRF) with cardiovascular disease risk factors and a biomarker of endothelial dysfunction (e-selectin) among Hispanic/Latino youth. Methods: The study included 1380 Hispanic/Latino youths (8–16 years old) from the Hispanic Community Children's Health Study/Study of Latino Youth that enrolled from four cities (Bronx, Chicago, Miami, and San Diego). CRF was assessed by a 3-minute step test that uses postexercise heart rate to estimate maximal oxygen uptake. Regression models assessed differences in cardiometabolic markers across quartiles of CRF, adjusting for potential confounders. Results: CRF was higher among boys (mean: 57.6 mL per kg/min, 95% confidence interval, 56.8–58.4) compared to girls (mean: 54.7 mL per kg/min, 95% confidence interval, 53.9–55.5). Higher levels of CRF were associated with more favorable levels of cardiometabolic, inflammation, and endothelial dysfunction factors (P-values <.001) and independently of physical activity and sedentary time. Compared to the lowest quartile of CRF, the odds of having greater than or equal to two cardiovascular disease risk factors was lower at higher quartiles of CRF, after adjustment for potential confounders. Conclusions: Among Hispanic/Latino youth, CRF appears to be a strong protective factor for endothelial dysfunction and cardiometabolic risk factors. Strategies to improve CRF may be a useful approach for improving cardiovascular health in youth.

Original languageEnglish (US)
Pages (from-to)583-589.e3
JournalAnnals of Epidemiology
Issue number9
StatePublished - Sep 2018



  • Cardiometabolic risk
  • Cardiorrespiratory fitness
  • Children
  • Endothelial function
  • Hispanic

ASJC Scopus subject areas

  • Epidemiology

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