The association between pain and prevalent and incident motoric cognitive risk syndrome in older adults

Guusje van der Leeuw, Emmeline Ayers, Annette H. Blankenstein, Henriëtte E. van der Horst, Joe Verghese

Research output: Contribution to journalArticle

Abstract

Background: The Motoric Cognitive Risk Syndrome (MCR) is a pre-dementia syndrome characterized by subjective cognitive complaints and slow gait in the absence of dementia and mobility disability. Worse cognitive and motoric function is associated with chronic pain in older adults. Our aim was to study the association between pain and prevalent and incident MCR in adults aged 65 years and older. Methods: We analyzed the cross-sectional association between severity of pain and prevalent MCR in 3244 older adults participating in the Health and Retirement Study (2008 wave) using logistic regression analysis adjusting for demographic, peripheral, central or biological risk factors. Additionally, we analyzed the longitudinal association between severity of pain and incident MCR in 362 participants in the Central Control of Mobility in Aging Study, using Cox regression analysis. Results: The 155 Health and Retirement Study participants with severe pain had an increased risk of prevalent MCR (n = 249), compared to 2245 individuals without pain (adjusted for demographics OR: 2.78, 95 % CI:1.74–4.45). Over a mean follow-up of 3.01 years (SD 1.38), 29 individuals in the Central Control of Mobility in Aging Study developed incident MCR. Older adults with severe pain had over a five times increased risk of developing incident MCR, compared to those without pain even after adjusting for demographic variables (HR: 5.44, 95 % CI: 1.81–16.40). Conclusion: Older adults with severe pain have a higher prevalence and incidence of MCR. These findings should be further explored to establish if pain is a potentially modifiable risk factor to prevent cognitive decline.

Original languageEnglish (US)
Article number103991
JournalArchives of Gerontology and Geriatrics
Volume87
DOIs
StatePublished - Mar 1 2020

Fingerprint

pain
incident
Pain
Retirement
Demography
Dementia
dementia
retirement
Regression Analysis
regression analysis
Health
Biological Factors
Gait
Chronic Pain
Cognition
health
complaint
Logistic Models
incidence
disability

Keywords

  • Aging
  • Cognition
  • Dementia
  • Epidemiology
  • Motoric cognitive risk syndrome
  • Pain

ASJC Scopus subject areas

  • Health(social science)
  • Aging
  • Gerontology
  • Geriatrics and Gerontology

Cite this

The association between pain and prevalent and incident motoric cognitive risk syndrome in older adults. / van der Leeuw, Guusje; Ayers, Emmeline; Blankenstein, Annette H.; van der Horst, Henriëtte E.; Verghese, Joe.

In: Archives of Gerontology and Geriatrics, Vol. 87, 103991, 01.03.2020.

Research output: Contribution to journalArticle

van der Leeuw, Guusje ; Ayers, Emmeline ; Blankenstein, Annette H. ; van der Horst, Henriëtte E. ; Verghese, Joe. / The association between pain and prevalent and incident motoric cognitive risk syndrome in older adults. In: Archives of Gerontology and Geriatrics. 2020 ; Vol. 87.
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abstract = "Background: The Motoric Cognitive Risk Syndrome (MCR) is a pre-dementia syndrome characterized by subjective cognitive complaints and slow gait in the absence of dementia and mobility disability. Worse cognitive and motoric function is associated with chronic pain in older adults. Our aim was to study the association between pain and prevalent and incident MCR in adults aged 65 years and older. Methods: We analyzed the cross-sectional association between severity of pain and prevalent MCR in 3244 older adults participating in the Health and Retirement Study (2008 wave) using logistic regression analysis adjusting for demographic, peripheral, central or biological risk factors. Additionally, we analyzed the longitudinal association between severity of pain and incident MCR in 362 participants in the Central Control of Mobility in Aging Study, using Cox regression analysis. Results: The 155 Health and Retirement Study participants with severe pain had an increased risk of prevalent MCR (n = 249), compared to 2245 individuals without pain (adjusted for demographics OR: 2.78, 95 {\%} CI:1.74–4.45). Over a mean follow-up of 3.01 years (SD 1.38), 29 individuals in the Central Control of Mobility in Aging Study developed incident MCR. Older adults with severe pain had over a five times increased risk of developing incident MCR, compared to those without pain even after adjusting for demographic variables (HR: 5.44, 95 {\%} CI: 1.81–16.40). Conclusion: Older adults with severe pain have a higher prevalence and incidence of MCR. These findings should be further explored to establish if pain is a potentially modifiable risk factor to prevent cognitive decline.",
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