The association between diazinon exposure and dyslipidemia occurrence: a systematic and meta-analysis study

Hamed Aramjoo, Tahereh Farkhondeh, Micheal Aschner, Kobra Naseri, Omid Mehrpour, Parisa Sadighara, Babak Roshanravan, Saeed Samarghandian

Research output: Contribution to journalReview articlepeer-review

Abstract

The effects of diazinon (DZN), an organophosphate pesticide, on lipid profiles have been extensively reported. However, controversy on this issue persists. Here, we performed a systematic and meta-analysis study to investigate the association between DZN exposure and dyslipidemia in rodents and fish species. This systematic review was prepared according to the PRISMA guidelines. Main databases, including Google Scholar, Scopus, PubMed, Ovid MEDLINE, and Web of Science, were systematically searched through March 4, 2020. The risk of bias was evaluated with the SYRCLE’s RoB tool. Once all articles were assessed for scientific quality, a random-effects model was applied to perform a pooled analysis. I2 and Q test were used to assess the heterogeneity between articles, and Forest plots, indicating point and pooled estimates, were drawn. Twenty-eight articles were included; between them, 13 publications were selected for meta-analysis. Random-effects meta-analysis showed low heterogeneity between the articles. A pooled analysis indicated that DZN significantly increased total cholesterol levels (95% CI: 0.86–3.79; Z = 3.10; p = 0.002), triglyceride (95% CI: 0.38–3.22; Z = 2.48; p = 0.09), low-density lipoprotein cholesterol (95% CI: 0.25–2.85; Z = 2.34; p = 0.7) in the DZN vs. control groups. In addition, DZN significantly decreased high-density lipoprotein cholesterol (95% CI: − 2.92, − 0.42; Z = 2.62; p = 0.07) in the DZN vs. control groups. No publication bias was observed. Our findings suggest that DZN induces dyslipidemia in rodents and fish species in a dose-dependent manner.

Original languageEnglish (US)
JournalEnvironmental Science and Pollution Research
DOIs
StateAccepted/In press - 2020

Keywords

  • Diazinon
  • Fish species
  • Lipid profile
  • Organophosphate pesticides
  • Rodents

ASJC Scopus subject areas

  • Environmental Chemistry
  • Pollution
  • Health, Toxicology and Mutagenesis

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